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Anti-Collagen I Antibody (clone 2G8) LS-C202650

Ordering

Wt. Vol. Conc. Price
100 µg - 2 mg/ml $545
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular Collagen I Antibodies

Anti-Collagen I Antibody IHC-plus™ LS-B342
Rabbit Polyclonal to Human Collagen I
Human, Mouse, Rat, Bovine
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Unconjugated
Immunohistochemistry Image
Anti-Collagen I Antibody IHC-plus™ LS-B3653
Rabbit Polyclonal (IgG) to Human Collagen I
Human
IHC - Paraffin, Immunofluorescence, ELISA
Unconjugated
Immunohistochemistry Image
Anti-Collagen I Antibody (clone COL-1) IHC-plus™ LS-B6723
Mouse Monoclonal [clone COL-1] (IgG1) to Bovine Collagen I
Bovine, Human, Rat, Pig, Rabbit, Deer
IHC - Paraffin, IHC - Frozen, IHC - 4% paraformaldehyde, Immunofluorescence, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone 2G8] (IgM) to Human Collagen I
Human
IHC - Frozen, ELISA
Unconjugated

Details

Human Collagen I
Mouse
Human (tested or 100% immunogen sequence identity)
IgM Monoclonal [2G8]
Unconjugated
Purified
Unmodified

Applications

  • IHC - Frozen
  • ELISA

Specificity and Use

Collagen I antibody was raised against human type I collagen (Sigma-Aldrich, C5483), digested with Collagenase from Clostridium histolyticum (Sigma-Aldrich, C0773). Synonyms for Collagenase from Clostridium histolyticum; Clostridiopeptidase A.
Collagens play a dominant role in maintaining the structural integrity of organs and tissues (1), but they also regulate cell polarity, migration, survival and phenotype, and provide diffusible signaling molecules following breakdown (2). Within the family of collagens that currently comprises 21 members, type I collagen is included in the group of fibril-forming collagens based on its structural and functional features. Type I collagen is ubiquitous in all vertebrates and is among the largest and most complex of all macromolecules. It accounts for 80-90% of all collagenous proteins in skin (3). The helical trimeric molecules of type I collagen compromise two a1(I) chains and one a2(I) chain, encoded by two separate genes Col(I)a1 and Col(I)a2, respectively (3). Matrix metalloproteinase (MMP)-1,-8, -13 and -14 cleave the peptide bonds between residues Gly775 and Ile776 of the a1(I) chain and Gly775 and Leu776 of the a2(I) chains, resulting in 1/4 and 3/4 fragments.

Packaging

100 mM Tris-HCl, pH 8.0, 50% glycerol, 0.05% sodium azide
Store at -20°C.
For research use only.

About Collagen I

Type I collagen is the most abundant collagen of the human body which forms large, eosinophilic fibers known as collagen fibers. It is present in scar tissue, the end product when tissue heals by repair, as well as tendons, ligaments, the endomysium of myofibrils, the organic part of bone, the dermis, the dentin and organ capsules. Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is encoded by the COL1A1 gene. Collagen alpha-2(I) chain is encoded by the COL1A2 gene.

Requested From: United States
Date Requested: 12/7/2016

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