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COL2A1 / Collagen II Alpha 1

collagen, type II, alpha 1

COL2A1 / Collagen II Alpha 1 is the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.

Gene Name: collagen, type II, alpha 1
Family/Subfamily: Collagen , not assigned-Collagen
Synonyms: COL2A1, Alpha-1 type II collagen, Cartilage collagen, COL11A3, Collagen alpha 1(ii), Collagen, type II, alpha 1, Collagen alpha-1(II) chain, Chondrocalcin, ANFH, AOM, SEDC
Target Sequences: NM_001844 NP_001835.3 P02458

Publications (4)

1
Atelocollagen promotes chondrogenic differentiation of human adipose-derived mesenchymal stem cells. Seon Ae Kim, Yoo Joon Sur, Mi-La Cho, Eun Jeong Go, Yun Hwan Kim, Asode Ananthram Shetty, Seok Jung Kim. Scientific reports. 2020 June;10:10678. [Full Text Article] [PubMed:32606308] [PMC:PMC7327030]
2
CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1. Go Jokoji, Shingo Maeda, Kazuki Oishi, Toshiro Ijuin, Masahiro Nakajima, Hiroki Tawaratsumida, Ichiro Kawamura, Hiroyuki Tominaga, Eiji Taketomi, Shiro Ikegawa, Noboru Taniguchi. The Journal of biological chemistry. 2021 Aug;;297:100994. [Full Text Article] [PubMed:34298017] [PMC:PMC8363834] Related Antibodies: LS-C175971.
3
MiR-99a alleviates apoptosis and extracellular matrix degradation in experimentally induced spine osteoarthritis by targeting FZD8. Yeyang Wang, Xiaoyu Zheng, Dixin Luo, Wangyang Xu, Xiaozhong Zhou. BMC musculoskeletal disorders. 2022 September;23:872. [Full Text Article] [PubMed:36127685] [PMC:PMC9487131] Related Antibodies: LS-C800256.
4
Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation. Imamura K, Maeda S, Kawamura I, Matsuyama K, Shinohara N, Yahiro Y, Nagano S, Setoguchi T, Yokouchi M, Ishidou Y, Komiya S. The Journal of biological chemistry. 2014 Apr;289:9865-79. [Full Text Article] [PubMed:24563464] [PMC:PMC3975031] Related Antibodies: LS-C175971.
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☰ Filters
Antibodies (57)
ELISA Kits (15)
Proteins (7)
Competitive EIA (1)
Custom (3)
Primary (57)
Recombinant (7)
Sandwich (10)
Sandwich CLIA (1)
COL2A1 / Collagen II Alpha 1 (79)
Human (35)
Mouse (29)
Rat (23)
Bovine (2)
Chicken (1)
Dog (2)
Horse (1)
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IHC (10)
IHC-Fr (1)
IHC-P (6)
WB (52)
ELISA (11)
IF (3)
Peptide-ELISA (1)
rabbit (52)
mouse (5)
Product Group
IHCPlus (1)
IgG (19)
IgG2a,k (1)
monoclonal mc (5)
polyclonal pc (52)
1E1 (1)
1H1 (1)
2F12D3 (1)
8F6 (1)
ABT-CII (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (2)
96-Well Strip Plate (12)
APC (4)
APC Conjugated (5)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (4)
Cy7 Conjugated (4)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (5)
Unconjugated (24)
aa1226-1331 (8)
aa1307-1383 (8)
aa1386-1467 (8)
aa677-817 (8)
aa1209-1237 (7)
aa1222-1241 (2)
70-150 aa, N-terminal (1)
N-Terminus (1)
Pro133 (1)
aa1228-1487 (1)
aa50-218 (1)
No (76)
Yes (3)
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Serum (12)
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His-GST-S (1)
Human (4)
Mouse (1)
Rabbit (1)
Rat (1)
E. coli (5)
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Purified (2)
Low endotoxin level (2)
COL2A1 / Collagen II Alpha 1 Antibody - IHC of Collagen II (P133) pAb in paraffin-embedded human breast carcinoma tissue.
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal (Pro133) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$321; 100 µl/$403
COL2A1 / Collagen II Alpha 1 Antibody - Western blot of COL2A1 antibody
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal (70-150 aa, N-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
COL2A1 / Collagen II Alpha 1 Antibody - Immunohistochemical analysis of Collagen 2 alpha 1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX. w
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
COL2A1 / Collagen II Alpha 1 Antibody - 1:200 staining human liver cells by IF/ICC. cells were formaldehyde fixed, permeabilized by Triton X-100 and blocked 5% BSA for 30 min at room temperature. The sample was incubated with the primary antibody (1:200 in BSA) for 1 hour. An Alexa Fluor 488®-conjugated Goat anti-rabbit antibody was used as the secondary.
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
COL2A1 / Collagen II Alpha 1 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.63 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$626
COL2A1 / Collagen II Alpha 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
2.5 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
COL2A1 / Collagen II Alpha 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$834
COL2A1 / Collagen II Alpha 1 Antibody - Collagen II antibody IHC-frozen: Rat Trachea Tissue.
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Mouse Polyclonal (aa1222-1241) Antibody
Mouse, Rat
IHC, IHC-Fr, WB
Unconjugated
10 µg/$318; 100 µg/$470
COL2A1 / Collagen II Alpha 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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COL2A1 / Collagen II Alpha 1 Mouse anti-Mouse Monoclonal (2F12D3) Antibody
Mouse, Rat
IHC
Unconjugated
60 µl/$307; 120 µl/$367; 200 µl/$457
COL2A1 / Collagen II Alpha 1 Antibody - Western blot analysis of extracts of mouse eye, using COL2A1 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 30s.
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal Antibody
Mouse
WB
Unconjugated
20 µl/$275; 100 µl/$389
COL2A1 / Collagen II Alpha 1 Antibody - Western blot of COL2A1 / Collagen II Alpha 1 antibody.
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal (aa1386-1467) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596; 2 ml/$824; 5 ml/$1,348
COL2A1 / Collagen II Alpha 1 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal (aa1228-1487) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$460
COL2A1 / Collagen II Alpha 1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
125 - 8000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
COL2A1 / Collagen II Alpha 1 Protein - Recombinant  Collagen Type II Alpha 1 By SDS-PAGE
Select
E. coli
His
13.5 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,745
COL2A1 / Collagen II Alpha 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
COL2A1 / Collagen II Alpha 1 Antibody - Immunohistochemistry of paraffin-embedded small intestine at dilution 1:100
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
Select
COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
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COL2A1 / Collagen II Alpha 1 Mouse anti-Human Monoclonal (1E1) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal (aa1209-1237) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal (aa1209-1237) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal (aa1209-1237) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal (aa1209-1237) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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COL2A1 / Collagen II Alpha 1 Rabbit anti-Human Polyclonal (aa1209-1237) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
COL2A1 / Collagen II Alpha 1 Antibody - Chondrosarcoma
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COL2A1 / Collagen II Alpha 1 Mouse anti-Human Monoclonal (ABT-CII) Antibody
Human
IHC
Unconjugated
50 µl/$316; 100 µl/$376
Viewing 1-25 of 79 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).