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Cochlin / COCH

cochlin

Cochlin / COCH is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.

Gene Name: cochlin
Synonyms: COCH, COCH5B2, COCH-5B2, Cochlin, DFNA9, DFNA31
Target Sequences: NM_004086 NP_004077.1 O43405

Publications (1)

1
Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9). Tomoko Honda, Norihito Kawasaki, Rei Yanagihara, Ryo Tamura, Karin Murakami, Tomomi Ichimiya, Naoki Matsumoto, Shoko Nishihara, Kazuo Yamamoto. PloS one. 2022 July;17:e0268485. [Full Text Article] [PubMed:35901072] [PMC:PMC9333281] Related Antibodies: LS-C334796.

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Antibodies (28)
Proteins (4)
ELISA Kits (2)
Custom (1)
Primary (28)
Recombinant (4)
Sandwich (1)
Cochlin / COCH (34)
Human (30)
Mouse (8)
Rat (6)
Bat (3)
Bovine (6)
Chimpanzee (6)
Dog (6)
Gibbon (6)
Guinea pig (6)
Horse (3)
Monkey (6)
Pig (3)
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Zebrafish (3)
IHC (10)
IHC-P (2)
WB (24)
Flo (7)
ELISA (15)
IF (2)
rabbit (27)
mouse (1)
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polyclonal pc (28)
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Unconjugated (12)
aa399-428 (7)
aa492-520 (7)
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aa141-190 (4)
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Human (3)
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HEK 293 Cells (2)
Human Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (3)
Cochlin / COCH Antibody - Immunohistochemistry of paraffin-embedded human prostate.
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Cochlin / COCH Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Cochlin / COCH Antibody - COCH Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining.
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Cochlin / COCH Rabbit anti-Human Polyclonal (aa399-428) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Cochlin / COCH Antibody - COCH antibody Western blot of Placenta lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Cochlin / COCH Rabbit anti-Human Polyclonal (aa141-190) Antibody
Human
WB
Unconjugated
100 µl/$424
Cochlin / COCH ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
Cochlin / COCH Antibody - COCH Antibody western blot of 293 cell line lysates (35 ug/lane). The COCH antibody detected the COCH protein (arrow).
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Cochlin / COCH Rabbit anti-Human Polyclonal (aa492-520) Antibody
Human
WB
Unconjugated
400 µl/$393
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Cochlin / COCH Rabbit anti-Human Polyclonal (aa399-428) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
200 µl/$734
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Cochlin / COCH Rabbit anti-Human Polyclonal (aa399-428) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
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Cochlin / COCH Rabbit anti-Human Polyclonal (aa399-428) (FITC) Antibody
Human
ELISA, Flo, IHC, WB
FITC Conjugated
200 µl/$952
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Cochlin / COCH Rabbit anti-Human Polyclonal (aa399-428) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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Cochlin / COCH Rabbit anti-Human Polyclonal (aa399-428) (PE) Antibody
Human
ELISA, Flo, IHC, WB
PE Conjugated
200 µl/$952
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Cochlin / COCH Rabbit anti-Human Polyclonal (aa399-428) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
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Cochlin / COCH Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Cochlin / COCH Antibody - Immunohistochemistry of paraffin-embedded Human endometrial cancer at dilution 1:100
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Cochlin / COCH Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
Select
Cochlin / COCH Rabbit anti-Human Polyclonal (aa492-520) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
Cochlin / COCH Rabbit anti-Human Polyclonal (aa492-520) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
Cochlin / COCH Rabbit anti-Human Polyclonal (aa492-520) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
Cochlin / COCH Rabbit anti-Human Polyclonal (aa492-520) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
Cochlin / COCH Rabbit anti-Human Polyclonal (aa492-520) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
Cochlin / COCH Rabbit anti-Human Polyclonal (aa492-520) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Cochlin / COCH Antibody - Western blot All Lanes: COCH antibody at 1.73ug/ml Lane 1 : Human placenta tissue Lane 2 : 293T whole cell lysate Secondary Goat polyclonal to Rabbit IgG at 1/10000 dilution Predicted band size: 60,54 kDa Observed band size: 59 kDa
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Cochlin / COCH Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µl/$294; 100 µl/$360
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Cochlin / COCH Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µg/$331
Cochlin / COCH Antibody - COCH antibody Western blot of Fetal Liver lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Cochlin / COCH Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
Cochlin / COCH Antibody - COCH antibody Western blot of Fetal Liver lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Cochlin / COCH Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Zebrafish, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
Cochlin / COCH Antibody - COCH antibody Western blot of Fetal Liver lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Cochlin / COCH Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Zebrafish, Rat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Gibbon, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100 µl/$469
Select
Cochlin / COCH Mouse anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µg/$705
Viewing 1-25 of 34 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).