Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
BCR Antibody, Acute lymphocytic leukemia Antibody, ALL Antibody, BCR1 Antibody, BCR/FGFR1 chimera protein Antibody, Breakpoint cluster region Antibody, Chronic myeloid leukemia Antibody, D22S11 Antibody, CML Antibody, D22S662 Antibody, Philadelphia chromosome Antibody, PHL Antibody, FGFR1/BCR chimera protein Antibody
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint.
Western blot of phospho Bcr (Y276) in recombinant fusion protein containing 1) a phosphorylated tyrosine at position 276 and 2) an unphosphorylated tyrosine at position 276, using Bcr phospho antibody at 0.01 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.