Human CLU / Clusterin

Rabbit

Human (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Purified

Unmodified

Recombinant human clusterin isoform 1.

Recognizes human clusterin, also known as apolipoprotein J, Ku70-binding protein 1 or TRPM-2. Clusterin is a ubiquitous glycoprotein which exists in at least two distinct isoforms; a proapoptotic nuclear form, of 49kD, and a prosurvival secretory form with a molecular weight of 75-80kD. Clusterin is implicated in several diverse physiological processes including sperm maturation, cell differentiation, and apoptosis. Clusterin upregulation has been reported in various human malignancies, including bladder, prostate, and breast tumors. Following specific stress induced injury, secretory clusterin acts as a molecular chaperone, scavenging denatured proteins outside cells. It has been shown to be upregulated in Alzheimer's€™s disease (Chen et al. 2012), retinitis pigmentosa (Jobes et al 1993), glomerulonephritis, atherosclerosis and myocardial infarction (Rosenberg et al. 2002).

• IHC - Paraffin
• Western blot (0.5 - 1 µg/ml)

Western Blot: LS-C42331 detects a band of approximately 60kD in human brain tissue lysate.

PBS, 0.02% Sodium Azide

Store at 4°C or at -20°C. Store undiluted. Avoid freeze-thaw cycles. Microcentrifugation recommended if solution contains precipitate.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P10909 NCBI: NM_001831 NP_001822.3