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Anti-CLU / Clusterin Antibody (clone Hs-3) LS-C204172


Wt. Vol. Conc. Price
100 µg - 1 mg/ml $345
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular CLU / Clusterin Antibodies

Anti-CLU / Clusterin Antibody (clone 3R3/2) LS-C44980
Mouse Monoclonal [clone 3R3/2] (IgG1) to Human CLU / Clusterin
IHC - Frozen, Western blot, Flow Cytometry, ELISA
Anti-CLU / Clusterin Antibody (aa75-501, Biotin) LS-C128238
Mouse Monoclonal (IgG2b) to Human CLU / Clusterin
Biotin Conjugated

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone Hs-3] (IgG1) to Human CLU / Clusterin
ICC, Western blot, ELISA


Human CLU / Clusterin
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [Hs-3]


  • ICC
  • Western blot

Specificity and Use

CLU / Clusterin antibody was raised against freshly ejaculated human sperms were washed in PBS and extracted in 3% acetic acid, 10% glycerol, 30 mM benzaminidine. The acid extract was dialyzed against 0.2% acetic acid and subsequently used for immunization.
Clusterin (SGP-2, SP-40,40, pADHC-9, TRPM-2, CLJ, T64, GP III, APO J, XIP8) is a 75-80 kD disulfide-linked heterodimeric protein containing about 30% of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified. It is a conserved secreted glycoprotein expressed by a wide range of tissues and being implicated in several physiological processes. Across a broad range of species clusterin shows a high degree of sequence homology ranging from 70% to 80%. It is nearly ubiqitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen. It is able to bind and form complexes with numerous partners such as immunoglobulins, lipids, heparin, bacteria, complement components, paraoxonase, beta amyloid, leptin and others. Clusterin has a number of functions such as phagocyte recruitment, aggregation induction, complement attack prevention, apoptosis inhibition, membrane remodeling, lipid transport, hormone transport and/or scavenging, matrix metalloproteinase inhibition. One tempting hypothesis says that clusterin is an extracellular chaperone protecting cells from stress-induced insults caused by degraded and misfolded protein precipitates. The protein is expressed in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others. A genuin


PBS, pH 7.4, 15 mM sodium azide
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About CLU / Clusterin

P10909 NM_001831 NP_001822.3

CLU Antibody, APO-J Antibody, Apolipoprotein J Antibody, CLU1 Antibody, Clusterin Antibody, Complement lysis inhibitor Antibody, CLI Antibody, AAG4 Antibody, Aging-associated protein 4 Antibody, Ku70-binding protein 1 Antibody, KUB1 Antibody, SGP2 Antibody, APOJ Antibody, SGP-2 Antibody, Sulfated glycoprotein 2 Antibody, CLU2 Antibody, Complement cytolysis inhibitor Antibody, NA1/NA2 Antibody, SP-40 Antibody

Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself.

Requested From: United States
Date Requested: 10/26/2016

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