Human CLEC7A / Dectin 1
(tested or 100% immunogen sequence identity)
Protein G purified
NIH3T3 cells expressing full length Beta-glucan receptor.
Recognizes human Dectin-1, also known as beta-glucan receptor (GR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (GR-A and GR-B) and several minor isoforms. GR-A and GR-B differs by the presence and absence, respectively, of a stalk region. The antibody (clone GE2) recognizes both of these isoforms. Clone GE2 could be used to inhibit receptor function.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
PBS, 0.09% sodium azide, 1% BSA, 5% sucrose
100 tst Distilled water
Store at 4°C. Do not freeze. Protect from light.
For research use only.
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