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Anti-CLEC7A / Dectin 1 Antibody (clone GE2) LS-C188491

Ordering

Wt. Vol. Conc. Price
100 µg - 1 mg/ml $270
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CLEC7A / Dectin 1 Antibodies

Anti-CLEC7A / Dectin 1 Antibody IHC-plus™ LS-B6303
Rabbit Polyclonal (IgG) to Human CLEC7A / Dectin 1
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-CLEC7A / Dectin 1 Antibody (Internal) IHC-plus™ LS-B8826
Rabbit Polyclonal to Human CLEC7A / Dectin 1
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-CLEC7A / Dectin 1 Antibody (clone 2A11, Biotin) LS-C188260
Rat Monoclonal [clone 2A11] (IgG2b) to Mouse CLEC7A / Dectin 1
Mouse
IHC - Frozen, Immunoprecipitation, Flow Cytometry
Biotin Conjugated
Flow Cytometry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone GE2] (IgG1) to Human CLEC7A / Dectin 1
Human
Flow Cytometry
Unconjugated

Details

Human CLEC7A / Dectin 1
Mouse
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [GE2]
Unconjugated
Protein G purified
Unmodified

Applications

Flow Cytometry (1:25 - 1:200)

Specificity and Use

CLEC7A / Dectin 1 antibody was raised against nIH3T3 cells expressing full length Beta-glucan receptor.
Recognizes human Dectin-1, also known as beta-glucan receptor (GR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (GR-A and GR-B) and several minor isoforms. GR-A and GR-B differs by the presence and absence, respectively, of a stalk region. The antibody (clone GE2) recognizes both of these isoforms. Clone GE2 could be used to inhibit receptor function.

Packaging

PBS, 0.09% sodium azide
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About CLEC7A / Dectin 1

Q9BXN2 NM_022570 NP_072092.2

CLEC7A Antibody, BGR Antibody, CANDF4 Antibody, CLECSF12 Antibody, Dectin-1 Antibody, DC-associated C-type lectin 1 Antibody, DECTIN1 Antibody, HDectin-1 Antibody, Beta-glucan receptor Antibody, Lectin-like receptor 1 Antibody

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia.

Requested From: United States
Date Requested: 12/8/2016

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