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Anti-CLEC7A / Dectin 1 Antibody (clone BD6, RPE) LS-C188495

Ordering

Wt. Vol. Conc. Price
- 100 tst - $375
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CLEC7A / Dectin 1 Antibodies

Anti-CLEC7A / Dectin 1 Antibody IHC-plus™ LS-B6303
Rabbit Polyclonal (IgG) to Human CLEC7A / Dectin 1
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-CLEC7A / Dectin 1 Antibody (Internal) IHC-plus™ LS-B8826
Rabbit Polyclonal to Human CLEC7A / Dectin 1
Human
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-CLEC7A / Dectin 1 Antibody (clone 2A11, Biotin) LS-C188260
Rat Monoclonal [clone 2A11] (IgG2b) to Mouse CLEC7A / Dectin 1
Mouse
IHC - Frozen, Immunoprecipitation, Flow Cytometry
Biotin Conjugated
Flow Cytometry Image

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone BD6] (IgG2b) to Human CLEC7A / Dectin 1
Human
Flow Cytometry
RPE Conjugated

Details

Human CLEC7A / Dectin 1
Mouse
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [BD6]
R. Phycoerythrin
Protein G purified
Unmodified

Applications

Flow Cytometry (1:1)

Specificity and Use

CLEC7A / Dectin 1 antibody was raised against nIH3T3 cells expressing full length Beta-glucan receptor.
Recognizes human Dectin-1, also known as beta-glucan receptor (GR), a C-type lectin domain family member. It is a major pathogen pattern-recognition receptor that binds beta-glucans, glucose polymers that form cell-wall components or exopolymers of yeasts, fungi and some bacteria. Beta-glucans have also been used experimentally and therapeutically as immunomodulators that enhance resistance to bacterial, yeast, viral and protozoan infections, as well as tumor formation. Dectin-1 also acts as a co-stimulatory molecule on T-cells to induce their proliferation and is necessary for the TLR2-mediated inflammatory response. It is highly expressed on peripheral blood leukocytes and dendritic cells. Human Dectin-1 has two major (GR-A and GR-B) and several minor isoforms. GR-A and GR-B differs by the presence and absence, respectively, of a stalk region. Clone BD6 recognizes GR-A only.
The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Packaging

PBS, 0.09% sodium azide, 1% BSA, 5% sucrose
100 tst Distilled water
Store at +4°C. Do not freeze. Protect from light.
For research use only.

About CLEC7A / Dectin 1

Q9BXN2 NM_022570 NP_072092.2

CLEC7A Antibody, BGR Antibody, CANDF4 Antibody, CLECSF12 Antibody, Dectin-1 Antibody, DC-associated C-type lectin 1 Antibody, DECTIN1 Antibody, HDectin-1 Antibody, Beta-glucan receptor Antibody, Lectin-like receptor 1 Antibody

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia.

Flow Cytometry

Flow Cytometry
Flow cytometry of human peripheral blood granulocytes with Mouse anti-Human Dectin-1:RPE This image was taken for the unconjugated form of this product. Other forms have not been tested.
 

Requested From: United States
Date Requested: 12/6/2016

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