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Anti-CLDN4 / Claudin 4 Antibody (C-Terminus) IHC-plus™ LS-B2370

Note: This antibody replaces LS-C6155

Ordering

Wt. Vol. Conc. Price
- 50 µl - $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CLDN4 / Claudin 4 Antibodies

Anti-CLDN4 / Claudin 4 Antibody LS-C35944
Mouse Monoclonal (IgG2a) to Human CLDN4 / Claudin 4
Human
Flow Cytometry, ELISA
Unconjugated
Anti-CLDN4 / Claudin 4 Antibody (C-Terminus) IHC-plus™ LS-B2257
Mouse Monoclonal (IgG1) to Human CLDN4 / Claudin 4
Human, Rat, Dog
IHC - Paraffin, Immunofluorescence, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (2)
Rabbit Polyclonal (IgG) to Human CLDN4 / Claudin 4
Human, Mouse
IHC - Paraffin
Unconjugated

Details

Human CLDN4 / Claudin 4
Rabbit
Human, Mouse (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

IHC - Paraffin (1:50)

Specificity and Use

CLDN4 / Claudin 4 antibody was raised against a synthetic peptide derived from the C-terminus of human Claudin 4.
C-Terminus
Recognizes human Claudin 4. Species cross-reactivity: mouse.
Immunohistochemistry: LS-B2370 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2370 was determined to be 1:50. Positive control: Tonsil and Ovarian carcinoma.

Packaging

10 mM PBS, pH 7.6, 0.2% BSA, 15 mM sodium azide, 40% glycerol.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

Publications (2)

1
Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium. Chen H, Hu Y, Fang Y, Djukic Z, Yamamoto M, Shaheen NJ, Orlando RC, Chen X. Gut. 2014 May;63:711-9. [Full Text Article] [PubMed:23676441] [PMC:PMC3883925]
2
Gastroesophageal reflux activates the NF- kappa B pathway and impairs esophageal barrier function in mice. Fang Y, Chen H, Hu Y, Djukic Z, Tevebaugh W, Shaheen NJ, Orlando RC, Hu J, Chen X. American journal of physiology. Gastrointestinal and liver physiology. 2013 Jul;305:G58-65. [PubMed:23639809] [PMC:PMC3725692]

About CLDN4 / Claudin 4

O14493 NM_001305 NP_001296.1

CLDN4 Antibody, Claudin-4 Antibody, CPE-receptor Antibody, CPETR Antibody, CPETR1 Antibody, Claudin 4 Antibody, CPE-R Antibody, HCPE-R Antibody, WBSCR8 Antibody, CPER Antibody

The protein encoded by this intronless gene belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life.

Immunohistochemistry

Immunohistochemistry
Anti-CLDN4 / Claudin 4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2370 dilution 1:50.
 

Requested From: United States
Date Requested: 12/7/2016

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