CIB1 / KIP

calcium and integrin binding 1 (calmyrin)

Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.Isoform 2: Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion.

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Antibodies (46)

Proteins (6)

ELISA Kits (4)

Type

Custom (4)

Over-Expression Lysate (2)

Primary (46)

Recombinant (4)

Target

CIB1 / KIP (56)

Reactivity

Human (46)

Mouse (7)

Rat (13)

Monkey (1)

Application

IHC (11)

IHC-Fr (1)

IHC-P (2)

WB (43)

ELISA (21)

IF (1)

Host

rabbit (27)

mouse (18)

sheep (1)

Isotype

IgG (14)

IgG1 (8)

IgG1,k (1)

IgG2a (2)

IgG2b (1)

IgG2b,k (1)

Clonality

monoclonal mc (17)

polyclonal pc (29)

Clone

1D1 (1)

4D2-3A8 (1)

5A1F5E12 (1)

5A1F5E12, 5A1H7E12 (1)

GF1 (1)

OTI1B8 (2)

OTI1D7 (2)

Format

96-Well Strip Plate (4)

APC (1)

APC Conjugated (3)

Azide-free (1)

Biotin Conjugated (4)

Carrier-free (2)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (3)

Unconjugated (26)

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Epitope

aa2-191 (13)

aa122-151 (7)

N-Terminus (4)

aa1-191 (2)

Internal (1)

aa6-191 (1)

Publications

No (56)

Tag

GST (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

Select

CIB1 / KIP Antibody (clone 4D2-3A8) LS-C133650

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (4D2-3A8) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$423

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CIB1 / KIP Antibody LS-C403065

Antibody:

CIB1 / KIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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CIB1 / KIP Antibody (aa1-191, clone 1D1) LS-C93725

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (aa1-191) (1D1) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$303; 100 µl/$365

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CIB1 / KIP Antibody (aa122-151) LS-C157645

Antibody:

CIB1 / KIP Rabbit anti-Human Polyclonal (aa122-151) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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CIB1 / KIP Antibody (clone 5A1F5E12) LS-C41441

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (5A1F5E12) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$435

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CIB1 / KIP Antibody (aa2-191, clone OTI1B8) LS-C795813

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (aa2-191) (OTI1B8) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$434

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CIB1 / KIP Antibody (aa2-191, clone OTI1B8, Carrier-free) LS-C792679

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (aa2-191) (Carrier-free) (OTI1B8) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

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CIB1 / KIP Antibody LS-C812426

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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CIB1 / KIP Antibody LS-C751951

Antibody:

CIB1 / KIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

CIB1 / KIP Antibody (clone GF1) LS-C190279

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (GF1) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µl/$688

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CIB1 / KIP Antibody (clone 5A1F5E12, 5A1H7E12) LS-C758497

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (5A1F5E12, 5A1H7E12) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$518

Select

CIB1 / KIP Antibody LS-C765543

Antibody:

CIB1 / KIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

Select

CIB1 / KIP Antibody (aa1-191) LS-C77545

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (aa1-191) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$586

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CIB1 / KIP Antibody LS-C12353

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$786

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CIB1 / KIP Antibody (HRP) LS-C543935

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$1,017

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CIB1 / KIP Antibody (Biotin) LS-C523809

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$1,017

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CIB1 / KIP Antibody (FITC) LS-C533837

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

100 µl/$1,017

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CIB1 / KIP Antibody (APC) LS-C515443

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

100 µl/$1,017

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CIB1 / KIP Antibody (PE) LS-C652031

Antibody:

CIB1 / KIP Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

100 µl/$1,017

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • PE

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CIB1 / KIP Antibody LS-C406306

Antibody:

CIB1 / KIP Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

Select

CIB1 / KIP Antibody (aa122-151) LS-C320395

Antibody:

CIB1 / KIP Rabbit anti-Human Polyclonal (aa122-151) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

CIB1 / KIP Antibody (aa122-151, Biotin) LS-C254876

Antibody:

CIB1 / KIP Rabbit anti-Human Polyclonal (aa122-151) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

CIB1 / KIP Antibody (aa122-151, FITC) LS-C254878

Antibody:

CIB1 / KIP Rabbit anti-Human Polyclonal (aa122-151) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

CIB1 / KIP Antibody (aa122-151, APC) LS-C254877

Antibody:

CIB1 / KIP Rabbit anti-Human Polyclonal (aa122-151) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

CIB1 / KIP Antibody (aa122-151, Azide-free, HRP) LS-C254880

Antibody:

CIB1 / KIP Rabbit anti-Human Polyclonal (aa122-151) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free

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