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Anti-CHUK / IKKA / IKK Alpha Antibody (aa553-582) LS-C157643

Catalog	Size	Price
LS-C157643-400	400 µl	Unavailable

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CHUK Antibody western blot of T47D cell line lysates (35 ug/lane). The CHUK antibody detected the CHUK protein (arrow).

Details

Target:	Human CHUK / IKKA / IKK Alpha
Host:	Rabbit
Reactivity:	Human (tested or 100% immunogen sequence identity)
Predicted:	Cow (at least 90% immunogen sequence identity)
Clonality:	Polyclonal
Conjugations:	Unconjugated
Purification:	Protein A purified
Modifications:	Unmodified

Applications

Approved:

Western blot (1:1000)

Specificity and Use

Blocking Peptide:

LS-E6773 - Lyophilized - 100 µg - $145.00
Immunizing peptide used to generate LS-C157643. Useful for pre-absorption and neutralization of the antibody's antigen binding site.

Epitope:

aa553-582

Specificity:

This CHUK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 553-582 amino acids from the C-terminal region of human CHUK.

Packaging

Presentation:	PBS, 0.09% sodium azide
Storage:	Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
Restrictions:	For research use only.

About CHUK / IKKA / IKK Alpha

Uniprot: O15111 NCBI: NM_001278 NP_001269.3

Synonyms: CHUK Antibody, I-kappa-B kinase alpha Antibody, I-kappa-B kinase-alpha Antibody, Ikb kinase alpha Antibody, IKK-A Antibody, IKBKA Antibody, IKK1 Antibody, NFKBIKA Antibody, I-kappa-B kinase 1 Antibody, IkappaB kinase Antibody, IKK Alpha Antibody, IKK-alpha Antibody, IKKA Antibody, Transcription factor 16 Antibody, IkappaBalpha Kinase Antibody, IkB kinase alpha subunit Antibody, IKK-a kinase Antibody, Ikkalpha Antibody, TCF-16 Antibody, TCF16 Antibody

Description: Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome.

(More About CHUK / IKKA / IKK Alpha)

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Western blot

CHUK Antibody western blot of T47D cell line lysates (35 ug/lane). The CHUK antibody detected the CHUK protein (arrow).

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Date Requested: 4/24/2018

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