CHRNA7

cholinergic receptor, nicotinic, alpha 7 (neuronal)

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants.

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Products

Antibodies (41)

ELISA Kits (6)

Proteins (2)

Type

Custom (2)

Primary (41)

Recombinant (2)

Sandwich (4)

Target

CHRNA7 (49)

Reactivity

Human (42)

Mouse (9)

Rat (10)

Bovine (6)

Chicken (6)

Chimpanzee (6)

Dog (1)

Gibbon (6)

Guinea pig (3)

Horse (4)

Monkey (11)

Pig (5)

Rabbit (3)

Zebrafish (1)

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Application

IHC (5)

IHC-P (3)

WB (38)

Flo (2)

ELISA (11)

ICC (1)

IF (1)

Peptide-ELISA (2)

Host

rabbit (37)

mouse (3)

goat (1)

Product Group

IHCPlus (1)

PathPlus Neuro (1)

Isotype

IgG (21)

IgG1 (2)

IgG2a (1)

Clonality

monoclonal mc (3)

polyclonal pc (38)

Clone

7F10F1 (1)

7F10G1 (1)

Format

96-Well Strip Plate (6)

APC (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (5)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (2)

Preservative Free (1)

Unconjugated (20)

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Epitope

aa23-502 (8)

aa8-37 (7)

aa22-71 (4)

aa398-447 (4)

aa424-473 (4)

C-Terminus (1)

Internal (1)

aa493-502 (1)

Publications

No (49)

Sample Type

Cell Lysates (1)

Plasma (3)

Serum (3)

Tissue Homogenates (1)

Tag

His (1)

His-GST, N-terminus (1)

Species

Human (2)

Source

E. coli (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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PathPlus™ CHRNA7 Antibody LS-B3716

Neuroscience

(5.0) Rating

Antibody:

CHRNA7 Goat anti-Human Polyclonal Antibody

Reactivity:

Chicken, Bovine, Pig, Horse, Dog, Human, Monkey

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µg/$485

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CHRNA7 Antibody (aa22-71) LS-C31192

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal (aa22-71) Antibody

Reactivity:

Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

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CHRNA7 Antibody (aa22-71, Biotin) LS-C481506

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal (aa22-71) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Rat, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$442

• Unconjugated
• Biotin

• Unconjugated
• Biotin

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CHRNA7 Antibody (clone 7F10G1) LS-C682517

Antibody:

CHRNA7 Mouse anti-Human Monoclonal (7F10G1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

100 µl/$459

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CHRNA7 Antibody (aa493-502) LS-C37657

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal (aa493-502) Antibody

Reactivity:

Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

100 µl/$732

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CHRNA7 Antibody (aa398-447) LS-C31194

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal (aa398-447) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$397

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Human CHRNA7 (Sandwich ELISA) ELISA Kit - LS-F49789

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human CHRNA7 (Sandwich ELISA) ELISA Kit - LS-F8631

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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CHRNA7 Antibody LS-C402467

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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CHRNA7 Antibody LS-C408325

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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CHRNA7 Antibody (aa8-37) LS-C168756

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal (aa8-37) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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CHRNA7 Antibody (clone 7F10F1) LS-C682516

Antibody:

CHRNA7 Mouse anti-Human Monoclonal (7F10F1) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

Unconjugated

Price:

100 µl/$459

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Human CHRNA7 Protein (Recombinant His-GST, N-terminus) (Gly23-Ala502) - LS-G24765

Source:

E. coli

Tag:

His-GST, N-terminus

Molecular Weight:

84.2 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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IHC-plus™ CHRNA7 Antibody LS-A11289

Fast Shipping

(4.0) Rating

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal Antibody

Applications:

IHC-P

Format:

Unconjugated

Price:

50 µg/$460

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CHRNA7 Antibody LS-C803554

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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CHRNA7 Antibody LS-C765533

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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CHRNA7 Antibody LS-C664582

Antibody:

CHRNA7 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$351

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CHRNA7 Antibody (aa8-37) LS-C320375

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal (aa8-37) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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CHRNA7 Antibody (aa8-37, Biotin) LS-C254799

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal (aa8-37) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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CHRNA7 Antibody (aa8-37, FITC) LS-C254800

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal (aa8-37) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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CHRNA7 Antibody (aa8-37, Azide-free, HRP) LS-C254801

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal (aa8-37) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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CHRNA7 Antibody (aa8-37, PE) LS-C254802

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal (aa8-37) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

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CHRNA7 Antibody (aa8-37, APC) LS-C254798

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal (aa8-37) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• PE
• APC

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • PE
  • APC

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CHRNA7 Antibody LS-C664581

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$331

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CHRNA7 Antibody (C-Terminus) LS-C73550

Antibody:

CHRNA7 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

5 ml/$694

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