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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CHRM3 / M3 Antibody (aa580‑589) LS‑C9135
Note: This antibody replaces LS-C37396
M3 antibody LS-C9135 is an unconjugated rabbit polyclonal antibody to M3 (CHRM3) from human and rat. Validated for ELISA, IHC and WB.
Antibody
Catalog
Size
Price
LS-C9135-100
100 µl (1 mg/ml)
Unavailable

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Anti-CHRM3 / M3 antibody LS-A5385 IHC of human brain, caudate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Antibody
Species: Human
Applications: IHC, Western blot, ELISA

Product Description

M3 antibody LS-C9135 is an unconjugated rabbit polyclonal antibody to M3 (CHRM3) from human and rat. Validated for ELISA, IHC and WB.
About CHRM3 / M3
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. P20309 NM_000740 NP_000731.1

CHRM3 Antibody, M3 Antibody, Muscarinic receptor M3 Antibody, Muscarinic M3 receptor Antibody, EGBRS Antibody, HM3 Antibody, M3 muscarinic receptor Antibody


Specifications

Target
Human CHRM3 / M3
Host
Rabbit
Reactivity
Human, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Applications
  • IHC
  • Western blot
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
CHRM3 / M3 antibody was raised against a peptide analogue of the carboxyl terminal of the M3 receptor covalently attached to a carrier protein.
Epitope
aa580-589
Specificity
Recognizes rat M3 Muscarinic Receptor (aa580-589): 100%; M3 Muscarinic Receptor 70%; M1 Muscarinic Receptor (aa451-460) 0%; M1 Muscarinic Receptor 0%; M2 Muscarinic Receptor (aa457-466) 0%; M2 Muscarinic Receptor 0%; M4 Muscarinic Receptor (aa469-478) 0%; M4 Muscarinic Receptor 0%; M5 Muscarinic Receptor (aa419-531) 0%; M5 Muscarinic Receptor 0%. This antibody is also specific for the COOH terminal of the M3 receptor as characterized by Western Blot, ELISA and IHC.
Usage
Suitable for use in ELISA, Immunohistochemistry and Western Blot. Immunohistochemistry: 10 ug/ml had been found to stain rat brain sections that express the muscarinic M3 receptor after fixing with PLP fixative and using ABC techniques. Western Blot: homogenates whole rat brain.
Presentation
PBS, 10 mg/ml BSA.
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 7/20/2018

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