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Anti-CHEMR23 / CMKLR1 Antibody (N-Terminus) LS-C44896

Note: This antibody replaces LS-C57993

Ordering

Wt. Vol. Conc. Price
200 µg - 1 mg/ml $375
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CHEMR23 / CMKLR1 Antibodies

Anti-CHEMR23 / CMKLR1 Antibody (N-Terminus) IHC-plus™ LS-A447
Rabbit Polyclonal to Human CHEMR23 / CMKLR1
Human
IHC - Paraffin, ICC
Unconjugated
Immunohistochemistry Image
Anti-CHEMR23 / CMKLR1 Antibody (C-Terminus) IHC-plus™ LS-A450
Rabbit Polyclonal to Human CHEMR23 / CMKLR1
Human
IHC - Paraffin
Unconjugated
Immunohistochemistry Image
Anti-CHEMR23 / CMKLR1 Antibody (N-Terminus, clone BZ332) IHC-plus™ LS-B2537
Rat Monoclonal [clone BZ332] (IgG2a) to Human CHEMR23 / CMKLR1
Human
IHC - Paraffin, Flow Cytometry
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rat Monoclonal (IgG2a) to Human CHEMR23 / CMKLR1
Human
Flow Cytometry
Unconjugated

Details

Human CHEMR23 / CMKLR1
Rat
Human (tested or 100% immunogen sequence identity)
IgG2a Monoclonal
Unconjugated
Protein G purified
Unmodified

Applications

Flow Cytometry (1:25 - 1:100)

Specificity and Use

CHEMR23 / CMKLR1 antibody was raised against peptide corresponding to an epitope within the N-terminal region of human CMKLR1.
N-Terminus
Recognizes human serpentine chemokine-like receptor 1 (CMKLR1), a novel chemoattractant receptor, which is also referred to Chem23 or DEZ. CMKLR1 is expressed on plasmacytoid dendritic cells (pDC) in blood but is not expressed on myeloid dendritic cells, lymphocytes, monocytes or granulocytes. Studies show that CMKLR1 is also expressed on dendritic cells, which have been generated in vitro from monocytes. The sole ligand for CMKLR1 is chemerin, a chemoattractant that exists at the mRNA level in a wide range of tissues, and as an inactive proform in serum and plasma. Studies suggest that chemerin, in plasma, is converted into a potent pDC attractant following blood coagulation and may be a process by which pDC's are recruited to sites of bleeding and tissue damage.
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request.

Packaging

PBS, pH 7.4, 0.09% sodium azide.
For research use only.

About CHEMR23 / CMKLR1

Q99788 NM_004072 NP_004063.1

CMKLR1 Antibody, Chemokine receptor-like 1 Antibody, DEZ Antibody, CHEMERINR Antibody, Resolvin E1 receptor Antibody, RVER1 Antibody, Chemokine-like receptor 1 Antibody, ChemR23 Antibody, G-protein coupled receptor DEZ Antibody

Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 induces activation of intracellular signaling molecules, such as SKY, MAPK1/3 (ERK1/2), MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B.

Requested From: United States
Date Requested: 12/7/2016

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