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Anti-CHEK2 / CHK2 Antibody (phospho-Thr68) LS-C42576

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $390
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CHEK2 / CHK2 Antibodies

Anti-CHEK2 / CHK2 Antibody LS-C123232
Rabbit Polyclonal (IgG) to Human CHEK2 / CHK2
Human, Monkey, Mouse, Rat, Bovine, Dog, Horse, Pig, Rabbit
IHC, Western blot
Unconjugated
Anti-CHEK2 / CHK2 Antibody (clone 4B7) IHC-plus™ LS-B6212
Mouse Monoclonal [clone 4B7] (IgG2a,k) to Human CHEK2 / CHK2
Human
IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Unconjugated
Immunohistochemistry Image
Anti-CHEK2 / CHK2 Antibody (phospho-Thr68) LS-C177890
Rabbit Polyclonal to Human CHEK2 / CHK2
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human CHEK2 / CHK2
Human
Western blot, ELISA
Unconjugated

Details

Human CHEK2 / CHK2
Rabbit
Human (tested or 100% immunogen sequence identity)
Mouse, Rat (at least 90% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Purified
Unmodified

Applications

  • Western blot (1:200 - 1:2000)
  • ELISA (1:10000 - 1:50000)

Specificity and Use

CHEK2 / CHK2 antibody was raised against synthetic peptide corresponding to amino acids 64-73 of human Chk2. ( pThr68 ).
pThr68
Detects human Checkpoint kinase 2 (Chk2), phosphorylated at threonine 68 (Thr68). Chk2 is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator. ATM and ATR kinases are activated in response to ionizing and ultraviolet radiation, and phosphorylate Thr68 and other sites in the amino-terminal region of Chk2, leading to Chk2 dimerization and activation. Activated Chk2 phosphorylates and inhibits Cdc25C phosphatase, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familial cancer usually associated with inherited mutations in TP53.
Western Blot: LS-C42576 detects a band of approximately 61kD.

Packaging

PBS, pH 7.2, 0.01% sodium azide.
For research use only.

About CHEK2 / CHK2

O96017 NM_007194 NP_009125.1

CHEK2 Antibody, BA444G7 Antibody, Cds1 homolog Antibody, Checkpoint kinase 2 Antibody, Checkpoint-like protein CHK2 Antibody, CHK2 checkpoint homolog Antibody, CHK2 Antibody, HCds1 Antibody, LFS2 Antibody, RAD53 Antibody, Rad53 homolog Antibody, HCHK2 Antibody, HuCds1 Antibody, PP1425 Antibody

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T].

Requested From: United States
Date Requested: 12/3/2016

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