CHD8

chromodomain helicase DNA binding protein 8

DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.

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Products

Antibodies (5)

ELISA Kits (3)

Proteins (2)

Type

Custom (3)

Primary (5)

Recombinant (2)

Target

CHD8 (10)

Reactivity

Human (6)

Mouse (4)

Rat (2)

Application

IHC (4)

IHC-P (1)

WB (3)

IP (2)

Peptide-ELISA (1)

Host

rabbit (5)

Isotype

IgG (4)

Clonality

polyclonal pc (5)

Format

96-Well Strip Plate (3)

Unconjugated (5)

Epitope

aa2252-2302 (2)

aa325-350 (1)

Publications

No (10)

Tag

GST, N-terminus (1)

His (1)

Species

Human (2)

Source

E. coli (1)

Wheat Germ Extract (1)

Low Endotoxin Level

Low endotoxin level (1)

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CHD8 Antibody (aa2252-2302) LS-C288034

Antibody:

CHD8 Rabbit anti-Human Polyclonal (aa2252-2302) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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CHD8 Antibody LS-C810296

Antibody:

CHD8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

CHD8 Antibody (aa325-350) LS-C288046

Antibody:

CHD8 Rabbit anti-Human Polyclonal (aa325-350) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

CHD8 Antibody (aa2252-2302) LS-C286494

Antibody:

CHD8 Rabbit anti-Human Polyclonal (aa2252-2302) Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

0.5 µg/$295; 100 µl/$532

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CHD8 Antibody LS-C778161

Antibody:

CHD8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC-P

Format:

Unconjugated

Price:

100 µg/$357

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Human CHD8 Protein (Recombinant GST, N-terminus) (aa1980-2078) - LS-G62992

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human CHD8 (Custom) ELISA Kit - LS-F66159

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Price:

1 Plate/$783

Select

Rat CHD8 (Custom) ELISA Kit - LS-F65369

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Price:

1 Plate/$783

Select

Mouse CHD8 (Custom) ELISA Kit - LS-F65532

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$783

Select

Human CHD8 Protein (Recombinant His) (aa451-720) - LS-G141067

Source:

E. coli

Sequence Length:

269 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

29.7 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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