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Anti-CHAT Antibody LS-C6076

Ordering

Wt. Vol. Conc. Price
- 50 µl - $575
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
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Rabbit Polyclonal (IgG) to Human CHAT
Human, Monkey, Mouse, Rat, Cat
IHC - Paraffin, Immunoprecipitation
Unconjugated

Details

Human CHAT
Rabbit
Human, Monkey, Mouse, Rat, Cat (tested or 100% immunogen sequence identity)
IgG Polyclonal
Antiserum

Applications

IHC - Paraffin, Immunoprecipitation (1:200)

Specificity and Use

CHAT antibody was raised against choline Acetyltransferase purified from human placenta.
Recognizes Cholinergic neurons in human brain and central nervous systems. Species cross-reactivity: rat, mouse, feline, monkey and bat.
Suitable for use in Immunohistochemistry and Immunoprecipitation. Immunohistochemistry (Paraffin): 1:100. Immunoreactivity is seen as a staining pattern on the cell body, dendrites and axons of neurons (brown). Immunoprecipitation: 1:200. Immunoprecipitates 68kD active ChAT from brain and placenta. Also precipitates a 27kD protein that is co-expressed with ChAT (but lacking ChAT activity) in some cholinergic neurons of the central nervous system of humans and possibly other mammals. Positive control: Cerebral cortex tissue.

Packaging

Supplied as a liquid. No preservatives added.
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
For research use only.

About CHAT

P28329 NM_020549 NP_065574.3

CHAT Antibody, Choline acetylase Antibody, Choline acetyltransferase Antibody, Choline O-acetyltransferase Antibody, CMS1A2 Antibody, CHOACTASE Antibody, CMS1A Antibody

CHAT is an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea.

Requested From: United States
Date Requested: 9/25/2016

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