CFI / Complement Factor I

complement factor I

CFI / Complement Factor I is a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.

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Products

Antibodies (112)

ELISA Kits (16)

Proteins (7)

Type

Custom (1)

Over-Expression Lysate (2)

Primary (112)

Recombinant (5)

Sandwich (15)

Target

CFI / Complement Factor I (135)

Reactivity

Human (111)

Mouse (15)

Rat (12)

Chicken (1)

Chimpanzee (6)

Gibbon (6)

Guinea pig (1)

Monkey (4)

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ID (2)

IF (3)

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Peptide-ELISA (1)

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rabbit (54)

mouse (56)

goat (1)

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IHCPlus (1)

Isotype

IgG (19)

IgG1 (33)

IgG2a (12)

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IgG2b,k (6)

Clonality

monoclonal mc (55)

polyclonal pc (57)

Clone

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Unconjugated (70)

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Epitope

aa340-583 (50)

aa28-243 (8)

aa358-603 (8)

aa145-194 (4)

aa511-560 (4)

Internal (2)

410-490 aa, Internal (1)

aa19-118 (1)

aa492-537 (1)

Publications

No (135)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (1)

Cell Supernatant (1)

Plasma (11)

Serum (11)

Tissue Homogenates (4)

Tag

GST, N-terminus (1)

His (2)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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IHC-plus™ CFI / Complement Factor I Antibody (clone OX-21) LS-B1620

(4.0) Rating

Antibody:

CFI / Complement Factor I Mouse anti-Human Monoclonal (OX-21) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, IHC-P, IP, RIA, WB

Format:

Unconjugated

Price:

125 µg/$460

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CFI / Complement Factor I Antibody (clone OX-21, Biotin) LS-C62861

Antibody:

CFI / Complement Factor I Mouse anti-Human Monoclonal (Biotin) (OX-21) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IP, RIA, WB

Format:

Biotin Conjugated

Price:

100 µg/$352

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CFI / Complement Factor I Antibody LS-C823996

Antibody:

CFI / Complement Factor I Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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CFI / Complement Factor I Antibody (aa358-603) LS-C374286

Antibody:

CFI / Complement Factor I Rabbit anti-Mouse Polyclonal (aa358-603) Antibody

Reactivity:

Mouse, Rat

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206

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CFI / Complement Factor I Antibody (aa340-583) LS-C293494

Antibody:

CFI / Complement Factor I Rabbit anti-Human Polyclonal (aa340-583) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

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CFI / Complement Factor I Antibody LS-C147802

Antibody:

CFI / Complement Factor I Sheep anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ID

Format:

Unconjugated

Price:

1 ml/$351

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CFI / Complement Factor I Antibody LS-C346093

Antibody:

CFI / Complement Factor I Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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Monkey CFI / Complement Factor I (Sandwich ELISA) ELISA Kit - LS-F42710

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

2.34 - 150 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$863

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Mouse CFI / Complement Factor I (Sandwich ELISA) ELISA Kit - LS-F15495

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$783

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Mouse CFI / Complement Factor I Protein (Recombinant His) (aa358-603) - LS-G24581

Source:

E. coli

Tag:

His

Molecular Weight:

31.3 kDa

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278

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Human CFI / Complement Factor I (Sandwich ELISA) ELISA Kit - LS-F21749

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

2.34 - 150 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$610

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Human CFI / Complement Factor I (Sandwich ELISA) ELISA Kit - LS-F5929

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$798

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CFI / Complement Factor I Antibody (aa145-194) LS-C146370

Antibody:

CFI / Complement Factor I Rabbit anti-Human Polyclonal (aa145-194) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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CFI / Complement Factor I Antibody (Internal) LS-C352346

Antibody:

CFI / Complement Factor I Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$299

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CFI / Complement Factor I Antibody (clone OX-21, FITC) LS-C62862

Antibody:

CFI / Complement Factor I Mouse anti-Human Monoclonal (FITC) (OX-21) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

100 µg/$361

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Human CFI / Complement Factor I Protein (Recombinant His-GST) (aa28-243) - LS-G14562

Source:

E. coli

Tag:

His-GST

Molecular Weight:

56.7 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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CFI / Complement Factor I Antibody (Internal) LS-C153419

Antibody:

CFI / Complement Factor I Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$440; 100 µg/$480

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CFI / Complement Factor I Antibody LS-C195842

Antibody:

CFI / Complement Factor I Goat anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, ID, WB

Format:

Unconjugated

Price:

1 ml/$391

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CFI / Complement Factor I Antibody (aa340-583, clone OTI6C1) LS-C339767

Antibody:

CFI / Complement Factor I Mouse anti-Human Monoclonal (aa340-583) (OTI6C1) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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CFI / Complement Factor I Antibody LS-C662409

Antibody:

CFI / Complement Factor I Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Flo, ICC, IHC, IHC-Fr, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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CFI / Complement Factor I Antibody (aa28-243) LS-C374287

Antibody:

CFI / Complement Factor I Rabbit anti-Human Polyclonal (aa28-243) Antibody

Reactivity:

Pig, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

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CFI / Complement Factor I Antibody (HRP) LS-C669931

Antibody:

CFI / Complement Factor I Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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CFI / Complement Factor I Antibody LS-C123314

Antibody:

CFI / Complement Factor I Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, Func, IHC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$926

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CFI / Complement Factor I Antibody (clone 3R/8) LS-C44983

Antibody:

CFI / Complement Factor I Mouse anti-Human Monoclonal (3R/8) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC-Fr, WB

Format:

Unconjugated

Price:

0.1 mg/$645

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CFI / Complement Factor I Antibody (aa340-583, clone OTI17C5) LS-C339812

Antibody:

CFI / Complement Factor I Mouse anti-Human Monoclonal (aa340-583) (OTI17C5) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$434

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