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Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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CENPF / CENP-F
centromere protein F, 350/400kDa
Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia.
Gene Name:
centromere protein F, 350/400kDa
Synonyms:
CENPF, AH antigen, Centromere protein F, CENF, CENP-F, Kinetochore protein CENPF, Mitosin, CENP-F kinetochore protein, Hcp-1, PRO1779
Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis. Sorensen CS, Lukas C, Kramer ER, Peters JM, Bartek J, Lukas J. Molecular and cellular biology. 2000 20:7613-23.
[PubMed:11003657]
[PMC:PMC86321]
2
Sgt1 is required for human kinetochore assembly. Steensgaard P, Garr M, Muradore I, Transidico P, Nigg EA, Kitagawa K, Earnshaw WC, Faretta M, Musacchio A. EMBO reports. 2004 5:626-31.
[PubMed:15133482]
[PMC:PMC1299074]
3
Human Cdc45 is a proliferation-associated antigen. Pollok S, Bauerschmidt C, Snger J, Nasheuer HP, Grosse F. The FEBS journal. 2007 274:3669-84.
[PubMed:17608804]
4
PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation. Yuan K, Li N, Jiang K, Zhu T, Huo Y, Wang C, Lu J, Shaw A, Thomas K, Zhang J, Mann D, Liao J, Jin C, Yao X. The Journal of biological chemistry. 2009 284:23072-82.
[PubMed:19553660]
[PMC:PMC2755713]
5
Silencing CENPF in bovine preimplantation embryo induces arrest at 8-cell stage. Toralov T, Susor A, Nemcov L, Kepkov K, Kanka J. Reproduction (Cambridge, England). 2009 138:783-91.
[PubMed:19651849]
ASURA (PHB2) Is Required for Kinetochore Assembly and Subsequent Chromosome Congression. Lee MH, Lin L, Equilibrina I, Uchiyama S, Matsunaga S, Fukui K. Acta histochemica et cytochemica. 2011 44:247-58.
[PubMed:22282585]
[PMC:PMC3263857]
8
Importin- negatively regulates multiple aspects of mitosis including RANGAP1 recruitment to kinetochores. Roscioli E, Di Francesco L, Bolognesi A, Giubettini M, Orlando S, Harel A, Schinin ME, Lavia P. The Journal of cell biology. 2012 196:435-50.
[PubMed:22331847]
[PMC:PMC3283988]
9
Live-cell imaging visualizes frequent mitotic skipping during senescence-like growth arrest in mammary carcinoma cells exposed to ionizing radiation. Suzuki M, Yamauchi M, Oka Y, Suzuki K, Yamashita S. International journal of radiation oncology, biology, physics. 2012 83:e241-50.
[PubMed:22365624]
10
Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivo. Bui M, Dimitriadis EK, Hoischen C, An E, Qunet D, Giebe S, Nita-Lazar A, Diekmann S, Dalal Y. Cell. 2012 150:317-26. (ICC; Human)
[PubMed:22817894]
[PMC:PMC3592566]
11
RBMX: a regulator for maintenance and centromeric protection of sister chromatid cohesion. Matsunaga S, Takata H, Morimoto A, Hayashihara K, Higashi T, Akatsuchi K, Mizusawa E, Yamakawa M, Ashida M, Matsunaga TM, Azuma T, Uchiyama S, Fukui K. Cell reports. 2012 1:299-308. (ICC; Human)
[PubMed:22832223]
Identification and mapping of a linear epitope of centromere protein F using monoclonal antibodies. Welner S, Trier NH, Houen G, Hansen PR. Journal of peptide science : an official publication of the European Peptide Society. 2013 19:95-101. (ELISA; Human)[Full Text Article]
[PubMed:23297090]
Related Antibodies: LS-B3157.
14
Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1. Bakr A, Köcher S, Volquardsen J, Petersen C, Borgmann K, Dikomey E, Rothkamm K, Mansour WY. Oncotarget. 2016 7:57679-57693. (IF; Human)[Full Text Article]
[PubMed:27494840]
[PMC:PMC5295381]
Related Antibodies: LS-B3046, LS-B276.
15
Loss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer. Mansour WY, Tennstedt P, Volquardsen J, Oing C, Kluth M, Hube-Magg C, Borgmann K, Simon R, Petersen C, Dikomey E, Rothkamm K. Scientific reports. 2018 March;8:3947. (Human)[Full Text Article]
[PubMed:29500400]
[PMC:PMC5834544]
Related Antibodies: LS-B3046, LS-B276.
16
Depletion of Akt1 and Akt2 Impairs the Repair of Radiation-Induced DNA Double Strand Breaks via Homologous Recombination. Mohammadian Gol T, Rodemann HP, Dittmann K. International journal of molecular sciences. 2019 December;20:E6316. [Full Text Article]
[PubMed:31847370]
[PMC:PMC6941063]
Related Antibodies: LS-B276.
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PLEASE NOTE
For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.
The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).
