Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 37B6] (IgG1,k) to Human CEA / Carcinoembryonic Antigen
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Mouse Monoclonal (IgG1) to Human CEA / Carcinoembryonic Antigen
IHC - Paraffin, IHC - Frozen
Human CEA / Carcinoembryonic Antigen
Human (tested or 100% immunogen sequence identity)
IHC - Paraffin
IHC - Frozen (1:10 - 1:40)
Specificity and Use
CEA is a glycoprotein constituent of embryonic endodermal epithelium. It is a complex molecule of 200kD. Specific for CEA, 85 A12 may be used in studying and monitoring primary and secondary tumors of the gastrointestinal tract. Strongly stains tumor cells present in cancerous colon tissue. Only very weak staining of normal tissue observed. Does not cross-react with NCA (Non-specific cross-reacting antigen), another member of the CEA family.
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
For research use only.
About CEA / Carcinoembryonic Antigen
Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion. CEA is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth. Therefore CEA is usually present only at very low levels in the blood of healthy adults. However, the serum levels are raised in some types of cancer, which means that it can be used as a tumor marker in clinical tests. Serum levels can also be elevated in heavy smokers.