Human CEA / Carcinoembryonic Antigen
(tested or 100% immunogen sequence identity)
- IHC - Paraffin
- IHC - Frozen (1:10 - 1:40)
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CEA is a glycoprotein constituent of embryonic endodermal epithelium. It is a complex molecule of 200kD. Specific for CEA, 85 A12 may be used in studying and monitoring primary and secondary tumors of the gastrointestinal tract. Strongly stains tumor cells present in cancerous colon tissue. Only very weak staining of normal tissue observed. Does not cross-react with NCA (Non-specific cross-reacting antigen), another member of the CEA family.
Immunohistochemistry: (frozen)- 1:10-1:40, (paraffin)- 1:10-1:40. Positive control: Colon Adenocarcinoma.
PBS, pH 7.2, 0.1% Sodium Azide
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
For research use only.
About CEA / Carcinoembryonic Antigen
Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion. CEA is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth. Therefore CEA is usually present only at very low levels in the blood of healthy adults. However, the serum levels are raised in some types of cancer, which means that it can be used as a tumor marker in clinical tests. Serum levels can also be elevated in heavy smokers.