Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 37B6] (IgG1,k) to Human CEA / Carcinoembryonic Antigen
IHC - Paraffin, Western blot, Immunoprecipitation, ELISA
Mouse Monoclonal [clone CLB-139] (IgG1) to Human CEA / Carcinoembryonic Antigen
Immunofluorescence, Flow Cytometry
Human CEA / Carcinoembryonic Antigen
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [CLB-139]
Specificity and Use
Directed against the CD66e-antigen, a 180-200 kD phosphoprotein, 90 kD PI-linked protein, which is expressed on mature human granulocytes. After activation of the granulocytes, expression the antigen is strongly increased. It reacts with 100% of mature human peripheral granulocytes. The monoclonal antibody reacts weakly with malignant cells of patients with B-cell derived chronic lymphoid leukemia (CLL). The monoclonal antibody does not react with normal human peripheral B-cells, T-cells, monocytes and platelets. In immunohistology the antibody reacts with a subpopulation of tissue macrophages and the Carcino Embryonic Antigen (CEA) expressed on colon carcinoma and other carcinomas.
1% BSA, 20 mM Tris, 150 mM sodium chloride, pH 8.0, 0.001% Merthiolate
For research use only.
About CEA / Carcinoembryonic Antigen
Carcinoembryonic antigen (CEA) describes a set of highly related glycoproteins involved in cell adhesion. CEA is normally produced in gastrointestinal tissue during fetal development, but the production stops before birth. Therefore CEA is usually present only at very low levels in the blood of healthy adults. However, the serum levels are raised in some types of cancer, which means that it can be used as a tumor marker in clinical tests. Serum levels can also be elevated in heavy smokers.