Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone H44] (IgG1,k) to Human CDw218a / IL18R1
Human CDw218a / IL18R1
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [H44]
Specificity and Use
This H44 antibody has been pre-titrated and tested by flow cytometric analysis on peripheral blood leukocytes and granulocytes. This can be used at 20 ul (0.25 ug)/per test. A test is defined as the amount (ug)/test of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
PBS, pH 7.2, 150 mM sodium chloride, 0.09% sodium azide
CDw218a / IL18R1 is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.
Staining of normal human peripheral blood cells with FITC Mouse IgG1, K isotype control (blue histogram) or FITC anti-human IL-18Ra (H44) (purple histogram). Cells in the granulocyte gate were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.