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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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CDKN2D / p19 INK4d
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CDKN2D / p19 INK4d is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.
| Gene Name: | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) |
| Synonyms: | CDKN2D, CDK inhibitor p19INK4d, INK4D, p19, p19 INK4d, p19-INK4D |
| Target Sequences: | NM_079421 NP_001791.1 P55273 |
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