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Anti-CDKN2A / p16INK4a Antibody (N-Terminus) IHC-plus™ LS-B1347

Note: This antibody replaces LS-C34699, LS-C56942

Ordering

Wt. Vol. Conc. Price
50 µg - 1 mg/ml $395
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CDKN2A / p16INK4a Antibodies

Anti-CDKN2A / p16INK4a Antibody (N-Terminus) IHC-plus™ LS-B1347
Rabbit Polyclonal (IgG) to Human CDKN2A / p16INK4a
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated
Immunohistochemistry Image
Anti-CDKN2A / p16INK4a Antibody (aa50-150) LS-C49180
Rabbit Polyclonal to Mouse CDKN2A / p16INK4a
Mouse
IHC - Paraffin, IHC - Frozen, ICC, Western blot, ELISA
Unconjugated
Western blot Image
Anti-CDKN2A / p16INK4a Antibody (clone 1E12E10) IHC-plus™ LS-B5261
Mouse Monoclonal [clone 1E12E10] (IgG1) to Human CDKN2A / p16INK4a
Human, Mouse, Rat
IHC - Paraffin, Western blot, ELISA
Unconjugated
Immunohistochemistry Image

100% Guaranteed 100% Guaranteed Publications Publications (2)
Rabbit Polyclonal (IgG) to Human CDKN2A / p16INK4a
Human, Mouse, Rat
IHC - Paraffin, Western blot
Unconjugated

Details

Human CDKN2A / p16INK4a
Rabbit
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Immunoaffinity purified
Unmodified

Applications

  • IHC - Paraffin (5 µg/ml)
  • Western blot (1 - 2 µg/ml)

Specificity and Use

CDKN2A / p16INK4a antibody was raised against a 18 amino acid peptide from near the amino terminus of human CDKN2A.
LS-E30347 - Liquid - 50 µg - $145.00
N-Terminus
Human CDKN2A / p16INK4a
Suitable for use in Immunofluorescence, ELISA Western Blot and Immunoprecipitation.

Packaging

PBS, 0.02% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles. Store undiluted.
For research use only.

Publications (2)

1
Tumor-promoting/progressing role of additional chromosome instability in hepatic carcinogenesis in Sgo1 (Shugoshin 1) haploinsufficient mice. Zhang Y, Reddy A, Mohammed A, Lightfoot S, Dai W, Rao CV. Carcinogenesis. Mar; [Full Text Article] [PubMed:25740822]
2
Antagonizing pathways leading to differential dynamics in colon carcinogenesis in Shugoshin1 (Sgo1)-haploinsufficient chromosome instability model. Sanghera S, Zhang Y, Biddick L, Reddy A, Lightfoot S, Dai W, Yamada HY. Molecular carcinogenesis. 2015 Mar; [Full Text Article] [PubMed:25773652]

About CDKN2A / p16INK4a

P42771 NM_000077 NP_000068.1

CDKN2A Antibody, ARF Antibody, Cdk4 inhibitor Antibody, CDK4 inhibitor p16-INK4 Antibody, INK4 Antibody, INK4A Antibody, Multiple tumor suppressor 1 Antibody, MTS-1 Antibody, MTS1 Antibody, p16-INK4 Antibody, p16-INK4A Antibody, p16INK4 Antibody, p19 Antibody, p14 Antibody, p16 Antibody, p16 INK4A Antibody, p16INK4A Antibody, p14ARF Antibody, TP16 Antibody, CDK4I Antibody, CDKN2 Antibody, CMM2 Antibody, MLM Antibody, p19ARF Antibody

Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.

Immunohistochemistry

Immunohistochemistry
Anti-p16INK4A antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1347 concentration 5 ug/ml.

Immunohistochemistry

Immunohistochemistry
Anti-p16INK4A antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1347 concentration 5 ug/ml.

Immunofluorescence

Immunofluorescence
Immunofluorescence of CDKN2A in Human Colon cells with CDKN2A antibody at 20 ug/ml.

Western blot

Western blot
Western blot of CDKN2A in mouse colon tissue lysate with CDKN2A antibody at (A) 1 and (B) 2 ug/ml.

Requested From: United States
Date Requested: 12/5/2016

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