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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CDKN1B / p27 Kip1 Antibody (phospho‑Thr187) LS‑C17122
P27 Kip1 antibody LS-C17122 is an unconjugated mouse monoclonal antibody to p27 Kip1 (CDKN1B) from human, mouse, rat and other species. Validated for ELISA and WB.
Antibody
Catalog
Size
Price
LS-C17122-100
100 µg
$605

Popular CDKN1B / p27 Kip1 Products

Anti-CDKN1B / p27 Kip1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5389 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Anti-CDKN1B / p27 Kip1 antibody IHC of human intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5740 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot
IHC of p27 on FFPE Breast Adenocarcinoma tissue.
Species: Human
Applications: IHC, IHC - Paraffin, IHC - Frozen
Anti-CDKN1B / p27 Kip1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3943 concentration 5 ug/ml.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Anti-CDKN1B / p27 Kip1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1465 dilution 1:500.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot

Product Description

P27 Kip1 antibody LS-C17122 is an unconjugated mouse monoclonal antibody to p27 Kip1 (CDKN1B) from human, mouse, rat and other species. Validated for ELISA and WB.

Specifications

Target
Human CDKN1B / p27 Kip1
Synonyms
CDKN1B, KIP1, MEN1B, P27 Kip1, p27KIP1, MEN4, CDKN4
Host
Mouse
Reactivity
Human, Mouse, Rat, Hamster (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Protein A purified
Modifications
Unmodified
Applications
  • Western blot (1 - 3 µg/ml)
  • ELISA (0.1 - 1 µg/ml)
  • (applications tested for the base form of this product only)
Immunogen
Synthetic peptide encompassing the phosphorylated Thr187 residue of human p27.
Epitope
pThr187
Specificity
Specific for p27 when phosphorylated at Thr187. On Western blots, it identifies the target band at ~27kD. It does not react with unphosphorylated p27. Specificity has been confirmed with Thr187-mutant p27 recombinant protein. Reactivity has been confirmed with p27-transfected 293 cells. Based on sequence homology, this antibody may also react with mouse, rat and hamster.
Usage
Suitable for use in ELISA and Western Blot. ELISA: 0.1-1 ug/ml. Western Blot: 1-3 ug/ml.
Presentation
PBS, pH 7.4, 0.1% Sodium Azide
Storage
Short term: 4°C; Long term: Add glycerol (40-50%) -20°C.
Restrictions
For research use only.
About CDKN1B / p27 Kip1
Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry. P46527 NM_004064 NP_004055.1


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Requested From: United States
Date Requested: 10/21/2018

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