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CDKN1A / WAF1 / p21
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1A / WAF1 / p21 is a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
| Gene Name: | cyclin-dependent kinase inhibitor 1A (p21, Cip1) |
| Synonyms: | CDKN1A, CDKN1, CIP1, CDK-interacting protein 1, DNA synthesis inhibitor, p21CIP1, MDA6, PIC1, SDI1, WAF1, CAP20, CDK-interaction protein 1, MDA-6, p21 |
| Target Sequences: | NM_078467 NP_000380.1 P38936 |
Publications (11)
1
The p21 cyclin-dependent kinase inhibitor suppresses tumorigenicity in vivo. Yang ZY, Perkins ND, Ohno T, Nabel EG, Nabel GJ. Nature medicine. 1995 1:1052-6.
[PubMed:7489362]
Related Antibodies: LS-C59514.
2
p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Waldman T, Kinzler KW, Vogelstein B. Cancer research. 1995 55:5187-90.
[PubMed:7585571]
Related Antibodies: LS-C59514.
3
A cis-acting element in Rous sarcoma virus long terminal repeat required for promoter repression by HeLa nuclear protein p21. Yeh CH, Shatkin AJ. The Journal of biological chemistry. 1995 270:15815-20.
[PubMed:7797584]
Related Antibodies: LS-C59514.
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(1)
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(168)
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(10)
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(8)
Target
CDKN1A / WAF1 / p21
(191)
Reactivity
Human
(150)
Mouse
(55)
Rat
(38)
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(6)
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(7)
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(2)
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(3)
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(3)
Monkey
(7)
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(1)
Orangutan
(3)
Pig
(3)
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(5)
Application
IHC
(90)
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(7)
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(37)
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(118)
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(21)
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(35)
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(115)
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(53)
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(81)
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(14)
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IgG1,k + IgG2b,k
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(11)
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(2)
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(2)
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(7)
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(13)
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(15)
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(1)
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(1)
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(1)
aa58-77
(1)
p145
(1)
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(187)
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(4)
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(2)
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(1)
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(9)
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(1)
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(1)
Source
293T Cells
(1)
E. coli
(6)
HEK 293 Cells
(2)
Wheat Germ Extract
(3)
Purification
Purified
(4)
CDKN1A / WAF1 / p21 Rabbit anti-Human Polyclonal (aa111-160) Antibody
Mouse, Rat, Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$440
CDKN1A / WAF1 / p21 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$332
CDKN1A / WAF1 / p21 Mouse anti-Human Monoclonal (WA-1) Antibody
Mouse, Rat, Human, Monkey
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
CDKN1A / WAF1 / p21 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
12 x 8-Well Microstrips
Human
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates
1 Plate/$771
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
CDKN1A / WAF1 / p21 Mouse anti-Human Monoclonal (HJ21) Antibody
Mouse, Rat, Chimpanzee, Human, Monkey
Flo, IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
![CDKN1A / WAF1 / p21 Antibody - Anti-Human p21WAF1 Monoclonal Antibody - Western Blot. Mab anti-Human p21WAF1 antibody (clone WA-1) is shown to detect human p21 by western blot. Detection occurs after 10 ug of a HeLa whole cell lysate is loaded per lane. The blot was incubated with a 1:1000 dilution of Mab anti-Human p21WAF1at room temperature for 30 min followed by detection using IRDye800 labeled Goat-a-Mouse IgG [H&L] ( diluted 1:5000. A single band corresponding to human p21WAF1 is detected at ~21 kD when compared with known molecular weight standards (not shown). The antibody may be used to detect endogenous human p21WAF1. IRDye800 fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results.](https://lsbio-7d62.kxcdn.com/image2/cdkn1a-waf1-p21-antibody-clone-wa-1-ls-c59514/62635_4867577.jpg)
CDKN1A / WAF1 / p21 Mouse anti-Human Monoclonal (WA-1) Antibody
Human
ELISA, IF, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100 µg/$574
CDKN1A / WAF1 / p21 Mouse anti-Human Monoclonal (DCS-60) Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
100 µg/$380
CDKN1A / WAF1 / p21 Rabbit anti-Human Polyclonal (pThr145) Antibody
Dog, Sheep, Bovine, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
CDKN1A / WAF1 / p21 Mouse anti-Human Monoclonal (DCS-60.2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
E. coli
His, N-Terminal
21kDa
10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$893
CDKN1A / WAF1 / p21 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, WB
Unconjugated
100 µl/$424
CDKN1A / WAF1 / p21 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Sheep, Bovine, Rat, Hamster, Pig, Orangutan, Gibbon, Chimpanzee, Human
IHC, WB
Biotin Conjugated
100 µl/$469
CDKN1A / WAF1 / p21 Mouse anti-Human Monoclonal (WA-1) Antibody
Human, Non-Human Primates
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
0.1 mg/$316
E. coli
6His, N-terminus
19.6 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
E. coli
GST
45.5 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Sandwich
12 x 8-Well Microstrips
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Cancer Pathology
Cancer
CDKN1A / WAF1 / p21 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC-P, WB
Unconjugated
50 µl/$460
CDKN1A / WAF1 / p21 Rabbit anti-Human Polyclonal (pThr145) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CDKN1A / WAF1 / p21 Mouse anti-Human Monoclonal (DCS-60.2) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$310
CDKN1A / WAF1 / p21 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Sheep, Bovine, Human
IP, WB
Unconjugated
100 µl/$299
CDKN1A / WAF1 / p21 Rabbit anti-Human Polyclonal (aa134-164) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
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of 191
product results
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