CDK8

cyclin-dependent kinase 8

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation.

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Products

Antibodies (53)

ELISA Kits (10)

Proteins (5)

Type

Cell-Based (1)

Over-Expression Lysate (2)

Primary (53)

Recombinant (3)

Sandwich (8)

Sandwich CLIA (1)

Target

CDK8 (68)

Reactivity

Human (58)

Mouse (24)

Rat (15)

Bovine (3)

Chicken (7)

Chimpanzee (6)

Dog (6)

Gibbon (6)

Hamster (3)

Horse (6)

Monkey (7)

Orangutan (3)

Pig (3)

Porcine (1)

Rabbit (7)

Xenopus (4)

Zebrafish (8)

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Application

IHC (8)

IHC-P (5)

WB (48)

Flo (2)

ELISA (25)

IF (1)

IP (2)

Peptide-ELISA (3)

Host

rabbit (45)

mouse (8)

Isotype

IgG (28)

IgG1 (1)

IgG1,k (7)

Clonality

monoclonal mc (8)

polyclonal pc (45)

Clone

6H5 (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (2)

96-Well Strip Plate (7)

APC (1)

APC Conjugated (4)

Azide-free (2)

Biotin Conjugated (6)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (6)

HRP Conjugated (6)

PE Conjugated (4)

Unconjugated (25)

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Epitope

aa21-392 (8)

aa1-30 (7)

aa245-272 (7)

N-Terminus (5)

C-Terminus (4)

aa420-470 (2)

10-90 aa, N-terminal (1)

aa1-50 (1)

aa249-277 (1)

aa365-464 (1)

aa370-420 (1)

aa375-464 (1)

aa400-464 (1)

aa424-458 (1)

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Publications

No (68)

Sample Type

Adherent Cell Cultures (1)

Plasma (3)

Serum (3)

Tissue Homogenates (3)

Tag

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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CDK8 Antibody (aa249-277) LS-C168617

Antibody:

CDK8 Rabbit anti-Human Polyclonal (aa249-277) Antibody

Reactivity:

Human

Applications:

Flo, WB

Format:

Unconjugated

Price:

400 µl/$393

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CDK8 Antibody (clone 6H5) LS-C196883

Antibody:

CDK8 Mouse anti-Human Monoclonal (6H5) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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CDK8 Antibody (aa420-470) LS-C289236

Antibody:

CDK8 Rabbit anti-Human Polyclonal (aa420-470) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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CDK8 Antibody LS-C664528

Antibody:

CDK8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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CDK8 Antibody (10-90 aa, N-terminal) LS-C382629

Antibody:

CDK8 Rabbit anti-Human Polyclonal (10-90 aa, N-terminal) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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CDK8 Antibody (aa365-464) LS-C375450

Antibody:

CDK8 Rabbit anti-Human Polyclonal (aa365-464) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µl/$261; 100 µl/$294

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CDK8 Antibody LS-C810124

Antibody:

CDK8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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CDK8 Antibody (N-Terminus) LS-C353939

Antibody:

CDK8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Zebrafish, Rat, Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$299

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CDK8 Antibody (aa370-420) LS-C289237

Antibody:

CDK8 Rabbit anti-Human Polyclonal (aa370-420) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP

Format:

Unconjugated

Price:

10 µg/$295; 100 µl/$514

Select

CDK8 Antibody (aa245-272) LS-C320274

Antibody:

CDK8 Rabbit anti-Mouse Polyclonal (aa245-272) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

CDK8 Antibody (aa245-272, FITC) LS-C254471

Antibody:

CDK8 Rabbit anti-Human Polyclonal (aa245-272) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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CDK8 Antibody (aa245-272, APC) LS-C254466

Antibody:

CDK8 Rabbit anti-Human Polyclonal (aa245-272) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

• Unconjugated
• FITC
• APC

• Unconjugated
• FITC
• APC

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CDK8 Antibody (aa375-464) LS-C190667

Antibody:

CDK8 Mouse anti-Human Monoclonal (aa375-464) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$705

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CDK8 Antibody (HRP) LS-C544999

Antibody:

CDK8 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$904

Select

CDK8 Antibody (Biotin) LS-C524877

Antibody:

CDK8 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

Select

CDK8 Antibody (FITC) LS-C534896

Antibody:

CDK8 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

100 µl/$904

Select

CDK8 Antibody (PE) LS-C653084

Antibody:

CDK8 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

100 µl/$904

Select

CDK8 Antibody (APC) LS-C515889

Antibody:

CDK8 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

100 µl/$904

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC

Select

CDK8 Antibody LS-C408850

Antibody:

CDK8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539

Select

CDK8 Antibody (aa1-30) LS-C320275

Antibody:

CDK8 Rabbit anti-Human Polyclonal (aa1-30) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

CDK8 Antibody (aa1-30, FITC) LS-C254477

Antibody:

CDK8 Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, WB

Format:

FITC Conjugated

Price:

200 µl/$952

• Unconjugated
• FITC

• Unconjugated
• FITC

Select

CDK8 Antibody (aa420-470) LS-C286910

Antibody:

CDK8 Rabbit anti-Human Polyclonal (aa420-470) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

Select

CDK8 Antibody (aa424-458) LS-C356407

Antibody:

CDK8 Rabbit anti-Mouse Polyclonal (aa424-458) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

CDK8 Antibody LS-C822749

Antibody:

CDK8 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

CDK8 Antibody (aa1-50) LS-C118905

Antibody:

CDK8 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Mouse, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Viewing 1-25 of 68 product results

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