CDK5R1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

CDK5R1 (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.

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Antibodies (29)

ELISA Kits (7)

Proteins (4)

Type

Cell-Based (1)

Custom (3)

Over-Expression Lysate (2)

Primary (29)

Recombinant (2)

Sandwich (3)

Target

CDK5R1 (40)

Reactivity

Human (32)

Mouse (13)

Rat (13)

Bat (3)

Bovine (4)

Chimpanzee (3)

Dog (3)

Guinea pig (3)

Horse (3)

Zebrafish (1)

Application

IHC (13)

WB (22)

ELISA (19)

ICC (1)

IF (12)

Peptide-ELISA (2)

Host

rabbit (23)

mouse (6)

Isotype

IgG (17)

IgG2a,k (6)

Clonality

monoclonal mc (6)

polyclonal pc (23)

Format

96-Well Microplate (1)

96-Well Strip Plate (6)

APC Conjugated (3)

Azide-free (2)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (3)

Unconjugated (11)

Epitope

C-Terminus (10)

N-Terminus (7)

Gln31 (1)

aa11-60 (1)

aa208-308 (1)

Publications

No (40)

Sample Type

Adherent Cell Cultures (1)

Plasma (3)

Serum (3)

Tissue Homogenates (2)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human CDK5R1 (Sandwich ELISA) ELISA Kit - LS-F17798

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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CDK5R1 Antibody (N-Terminus) LS-C353102

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Zebrafish, Rat, Mouse, Bovine, Human

Applications:

ICC, IF, WB

Format:

Unconjugated

Price:

100 µl/$299

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CDK5R1 Antibody (aa208-308) LS-C306883

Antibody:

CDK5R1 Mouse anti-Human Monoclonal (aa208-308) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$705

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CDK5R1 Antibody (HRP) LS-C541405

Antibody:

CDK5R1 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$904

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CDK5R1 Antibody (Biotin) LS-C521272

Antibody:

CDK5R1 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

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CDK5R1 Antibody (FITC) LS-C531316

Antibody:

CDK5R1 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

FITC Conjugated

Price:

100 µl/$904

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CDK5R1 Antibody (PE) LS-C649517

Antibody:

CDK5R1 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

PE Conjugated

Price:

100 µl/$904

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CDK5R1 Antibody (APC) LS-C513058

Antibody:

CDK5R1 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

APC Conjugated

Price:

100 µl/$904

• Unconjugated
• HRP
• Biotin
• FITC
• PE
• APC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • PE
  • APC

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CDK5R1 Antibody (Gln31) LS-C176814

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (Gln31) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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CDK5R1 Antibody (C-Terminus) LS-C329351

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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CDK5R1 Antibody (C-Terminus, Biotin) LS-C208335

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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CDK5R1 Antibody (C-Terminus, FITC) LS-C208336

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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CDK5R1 Antibody (C-Terminus, APC) LS-C208334

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (C-Terminus) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

CDK5R1 Antibody (C-Terminus, PE) LS-C208338

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (C-Terminus) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

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CDK5R1 Antibody (C-Terminus, Azide-free, HRP) LS-C208337

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (C-Terminus) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

CDK5R1 Antibody LS-C822939

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$357

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CDK5R1 Antibody (aa11-60) LS-C119052

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (aa11-60) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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CDK5R1 Antibody LS-C804546

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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CDK5R1 Antibody (N-Terminus) LS-C329352

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

200 µl/$734

Select

CDK5R1 Antibody (N-Terminus, Biotin) LS-C208341

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

CDK5R1 Antibody (N-Terminus, FITC) LS-C208342

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

FITC Conjugated

Price:

200 µl/$952

Select

CDK5R1 Antibody (N-Terminus, APC) LS-C208340

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (N-Terminus) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

APC Conjugated

Price:

200 µl/$952

Select

CDK5R1 Antibody (N-Terminus, PE) LS-C208344

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (N-Terminus) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

PE Conjugated

Price:

200 µl/$952

Select

CDK5R1 Antibody (N-Terminus, Azide-free, HRP) LS-C208343

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal (N-Terminus) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

CDK5R1 Antibody LS-C749498

Antibody:

CDK5R1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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