CDK4

cyclin-dependent kinase 4

Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

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Products

Antibodies (103)

ELISA Kits (18)

Proteins (15)

Type

Competitive EIA (1)

Custom (5)

Over-Expression Lysate (2)

Primary (103)

Recombinant (13)

Sandwich (11)

Sandwich CLIA (1)

Target

CDK4 (136)

Reactivity

Human (93)

Mouse (52)

Rat (49)

Bovine (4)

Chicken (1)

Chimpanzee (6)

Dog (7)

Gibbon (6)

Guinea pig (1)

Monkey (9)

Pig (7)

Porcine (1)

Rabbit (8)

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Application

IHC (31)

IHC-Fr (1)

IHC-P (9)

WB (100)

Flo (8)

ELISA (31)

Func (2)

ICC (6)

IF (9)

IP (19)

Peptide-ELISA (2)

RNAi (1)

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Host

rabbit (78)

mouse (24)

goat (1)

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IHCPlus (1)

Isotype

IgG (47)

IgG1 (11)

IgG1,k (3)

IgG2a (4)

IgG2a,k (2)

Clonality

monoclonal mc (23)

polyclonal pc (80)

Clone

10B2179 (1)

1529CT850.162.73 (1)

4F11 (1)

AT6D10 (1)

DCS-156 (3)

DCS-35 (2)

IML-4 (3)

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12 x 8-Well Microstrips (1)

96-Well Microplate (1)

96-Well Strip Plate (16)

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Azide-free (3)

Biotin Conjugated (9)

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HRP Conjugated (9)

Magnetic beads Conjugated (1)

PE Conjugated (6)

Preservative Free (2)

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Epitope

aa6-295 (16)

C-Terminus (10)

aa219-246 (7)

aa273-305 (7)

N-Terminus (2)

1-50 aa, N-terminal (1)

aa1-20 (1)

aa1-303 (1)

aa1-50 (1)

aa201-303 (1)

aa211-304 (1)

aa253-303 (1)

aa272-303 (1)

aa279-300 (1)

aa283-303 (1)

aa291-303 (1)

pThr172 (1)

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Publications

No (136)

Sample Type

Cell Lysates (1)

Plasma (7)

Serum (7)

Tissue Homogenates (2)

Tag

6His, N-terminus (2)

GST (4)

GST, N-terminus (1)

His (4)

His, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (13)

Mouse (1)

Source

293T Cells (1)

Baculovirus (2)

E. coli (6)

HEK 293 Cells (2)

Wheat Germ Extract (4)

Purification

Purified (6)

Low Endotoxin Level

Low endotoxin level (1)

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CDK4 Antibody (clone 1529CT850.162.73) LS-C392591

Antibody:

CDK4 Mouse anti-Human Monoclonal (1529CT850.162.73) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

200 µl/$393

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CDK4 Antibody (aa273-305) LS-C99873

Antibody:

CDK4 Rabbit anti-Human Polyclonal (aa273-305) Antibody

Reactivity:

Human

Applications:

Flo, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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CDK4 Antibody (clone DCS-156) LS-C22048

Antibody:

CDK4 Mouse anti-Human Monoclonal (DCS-156) Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$832

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Human CDK4 (Sandwich ELISA) ELISA Kit - LS-F4493

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$798

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CDK4 Antibody (phospho-Thr172) LS-C411605

Antibody:

CDK4 Rabbit anti-Human Polyclonal (pThr172) Antibody

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$287; 50 µl/$341; 100 µl/$431; 200 µl/$539

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CDK4 Antibody LS-C137013

Antibody:

CDK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µl/$332

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CDK4 Antibody (aa6-295) LS-C293584

Antibody:

CDK4 Rabbit anti-Human Polyclonal (aa6-295) Antibody

Reactivity:

Rat, Human

Applications:

ICC, IP, WB

Format:

Unconjugated

Price:

100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182

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CDK4 Antibody LS-C285719

Antibody:

CDK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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CDK4 Antibody (aa219-246, Azide-free, HRP) LS-C254436

Antibody:

CDK4 Rabbit anti-Mouse Polyclonal (aa219-246) (Azide-free) (HRP) Antibody

Reactivity:

Mouse

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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CDK4 Antibody (aa279-300) LS-C63193

Antibody:

CDK4 Rabbit anti-Human Polyclonal (aa279-300) Antibody

Reactivity:

Rabbit, Sheep, Rat, Human, Monkey

Applications:

IP, WB

Format:

Unconjugated

Price:

25 µl/$271

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CDK4 Antibody LS-C178280

Antibody:

CDK4 Mouse anti-Human Monoclonal Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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CDK4 Antibody LS-C664527

Antibody:

CDK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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CDK4 Antibody (clone 4F11) LS-C196880

Antibody:

CDK4 Mouse anti-Human Monoclonal (4F11) Antibody

Reactivity:

Human

Applications:

ELISA, IF, RNAi, WB

Format:

Unconjugated

Price:

100 µg/$423

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CDK4 Antibody (Preservative Free) LS-C817885

Antibody:

CDK4 Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, IF, IHC-P, IP, WB

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

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CDK4 Antibody (aa273-305) LS-C320270

Antibody:

CDK4 Rabbit anti-Human Polyclonal (aa273-305) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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CDK4 Antibody (aa273-305, Biotin) LS-C254440

Antibody:

CDK4 Rabbit anti-Human Polyclonal (aa273-305) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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CDK4 Antibody (aa273-305, FITC) LS-C254441

Antibody:

CDK4 Rabbit anti-Human Polyclonal (aa273-305) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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CDK4 Antibody (aa273-305, APC) LS-C254439

Antibody:

CDK4 Rabbit anti-Human Polyclonal (aa273-305) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

CDK4 Antibody (aa273-305, PE) LS-C254447

Antibody:

CDK4 Rabbit anti-Human Polyclonal (aa273-305) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

CDK4 Antibody (aa273-305, Azide-free, HRP) LS-C254446

Antibody:

CDK4 Rabbit anti-Human Polyclonal (aa273-305) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

CDK4 Antibody LS-C330939

Antibody:

CDK4 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Select

IHC-plus™ CDK4 Antibody (aa1-50) LS-B13047

(4.0) Rating

Antibody:

CDK4 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$460

Select

CDK4 Antibody (Preservative Free) LS-C815551

Antibody:

CDK4 Rabbit anti-Human Polyclonal (Preservative Free) Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC-P, IP, WB

Format:

Unconjugated, Preservative Free

Price:

100 µl/$412

Select

CDK4 Antibody (clone DCS-35) LS-C22049

Antibody:

CDK4 Mouse anti-Human Monoclonal (DCS-35) Antibody

Reactivity:

Mouse, Rat, Pig, Human

Applications:

Func, IF, IP, WB

Format:

Unconjugated

Price:

50 µg/$801

Select

CDK4 Antibody (aa1-20) LS-C22031

Antibody:

CDK4 Mouse anti-Human Monoclonal (aa1-20) Antibody

Reactivity:

Mouse, Rat, Pig, Human

Applications:

Func, IF, IP, WB

Format:

Unconjugated

Price:

500 µl/$887

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