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CDK13 / CDC2L5
cyclin-dependent kinase 13
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
| Gene Name: | cyclin-dependent kinase 13 |
| Family/Subfamily: | Protein Kinase , CDC2/CDK |
| Synonyms: | CDK13, CDC2L, CDC2L5, CHED, Cyclin-dependent kinase 13, HCDK13, KIAA1791, CDC2-related protein kinase 5 |
| Target Sequences: | NM_003718 NP_003709.3 Q14004 |
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