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CDH2 / N Cadherin

cadherin 2, type 1, N-cadherin (neuronal)

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.

Gene Name:	cadherin 2, type 1, N-cadherin (neuronal)
Family/Subfamily:	Cadherin , not assigned-Cadherin
Synonyms:	CDH2, CDw325, CDHN, Cadherin-2, CD325, CD325 antigen, N Cadherin, N-cadherin, NCAD, Neural cadherin, N-cadherin 1, Neural-cadherin
Target Sequences:	NM_001792 NP_001783.2 P19022

Publications (21)

Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. Sacco PA, McGranahan TM, Wheelock MJ, Johnson KR. The Journal of biological chemistry. 1995 270:20201-6. [PubMed:7650039]

Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin. Knudsen KA, Soler AP, Johnson KR, Wheelock MJ. The Journal of cell biology. 1995 130:67-77. [PubMed:7790378] [PMC:PMC2120515]

The differential expression of N-cadherin and E-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas. Peralta Soler A, Knudsen KA, Jaurand MC, Johnson KR, Wheelock MJ, Klein-Szanto AJ, Salazar H. Human pathology. 1995 26:1363-9. [PubMed:8522310]

Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion. Islam S, Carey TE, Wolf GT, Wheelock MJ, Johnson KR. The Journal of cell biology. 1996 135:1643-54. [PubMed:8978829] [PMC:PMC2133960]

N-cadherin promotes adhesion between invasive breast cancer cells and the stroma. Hazan RB, Kang L, Whooley BP, Borgen PI. Cell adhesion and communication. 1997 4:399-411. [PubMed:9177902]

Differential expression of N-cadherin in pleural mesotheliomas and E-cadherin in lung adenocarcinomas in formalin-fixed, paraffin-embedded tissues. Han AC, Peralta-Soler A, Knudsen KA, Wheelock MJ, Johnson KR, Salazar H. Human pathology. 1997 28:641-5. [PubMed:9190996]

Expression of E-cadherin and N-cadherin in surface epithelial-stromal tumors of the ovary distinguishes mucinous from serous and endometrioid tumors. Peralta Soler A, Knudsen KA, Tecson-Miguel A, McBrearty FX, Han AC, Salazar H. Human pathology. 1997 28:734-9. [PubMed:9191009]

Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization. Navarro P, Ruco L, Dejana E. The Journal of cell biology. 1998 140:1475-84. [PubMed:9508779] [PMC:PMC2132661]

N-cadherin redistribution during synaptogenesis in hippocampal neurons. Benson DL, Tanaka H. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 18:6892-904. [PubMed:9712659]

N-cadherin-mediated human granulosa cell adhesion prevents apoptosis: a role in follicular atresia and luteolysis?. Makrigiannakis A, Coukos G, Christofidou-Solomidou M, Gour BJ, Radice GL, Blaschuk O, Coutifaris C. The American journal of pathology. 1999 154:1391-406. [PubMed:10329592] [PMC:PMC1866595]

N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. Nieman MT, Prudoff RS, Johnson KR, Wheelock MJ. The Journal of cell biology. 1999 147:631-44. [PubMed:10545506] [PMC:PMC2151177]

Expression of E-, P-, n-cadherins and catenins in human bladder carcinoma cell lines. Mialhe A, Levacher G, Champelovier P, Martel V, Serres M, Knudsen K, Seigneurin D. The Journal of urology. 2000 164:826-35. [PubMed:10953163]

N-Cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility. Kim JB, Islam S, Kim YJ, Prudoff RS, Sass KM, Wheelock MJ, Johnson KR. The Journal of cell biology. 2000 151:1193-206. [PubMed:11121435] [PMC:PMC2190584]

Truncated DCC reduces N-cadherin/catenin expression and calcium-dependent cell adhesion in neuroblastoma cells. Reyes-Mgica M, Meyerhardt JA, Rzasa J, Rimm DL, Johnson KR, Wheelock MJ, Reale MA. Laboratory investigation; a journal of technical methods and pathology. 2001 81:201-10. [PubMed:11232642]

Structure and function of the N-cadherin/catenin complex in retinoblastoma. Van Aken EH, Papeleu P, De Potter P, Bruyneel E, Philipp J, Seregard S, Kvanta A, De Laey JJ, Mareel MM. Investigative ophthalmology & visual science. 2002 43:595-602. [PubMed:11867572]

N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane. Wahl JK, Kim YJ, Cullen JM, Johnson KR, Wheelock MJ. The Journal of biological chemistry. 2003 278:17269-76. [PubMed:12604612]

N-cadherin switching occurs in high Gleason grade prostate cancer. Jaggi M, Nazemi T, Abrahams NA, Baker JJ, Galich A, Smith LM, Balaji KC. The Prostate. 2006 66:193-9. [PubMed:16173043]

The role of the sca-1+/CD31- cardiac progenitor cell population in postinfarction left ventricular remodeling. Wang X, Hu Q, Nakamura Y, Lee J, Zhang G, From AH, Zhang J. Stem cells (Dayton, Ohio). 2006 24:1779-88. [PubMed:16614004]

Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn). Maeda M, Johnson E, Mandal SH, Lawson KR, Keim SA, Svoboda RA, Caplan S, Wahl JK, Wheelock MJ, Johnson KR. Oncogene. 2006 25:4595-604. [PubMed:16786001]

Microarray analysis sheds light on the dedifferentiating role of agouti signal protein in murine melanocytes via the Mc1r. Le Pape E, Passeron T, Giubellino A, Valencia JC, Wolber R, Hearing VJ. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:1802-7. (WB) [PubMed:19174519] [PMC:PMC2644118]

Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112] Related Antibodies: LS-C172138.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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