Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 67A4] (IgG1) to Human CDH1 / E Cadherin
Western blot, Immunoprecipitation
Human CDH1 / E Cadherin
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [67A4]
Western blot (1:100)
Specificity and Use
CDH1 / E Cadherin antibody was raised against bALB/C mice were injected with human thoracic duct lymphocytes (TDL).
Specificity:is specific to E-cadherin of 123 kD molecule of the cadherin family. E-cadherin is expressed on non-neuronal epithelial cells. This antibody reacts with tumor cell lines such as breast carcinoma cells.
CDH1 / E Cadherin is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis.