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Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Plays an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1.
Gene Name: | cell division cycle associated 7-like |
Synonyms: | CDCA7L, HR1, JPO2, R1, RAM2, Protein JPO2, Transcription factor RAM2 |
Target Sequences: | NM_018719 NP_061189.2 Q96GN5 |
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