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CDC25A

cell division cycle 25A

CDC25A, a CDC25 dual specificity protein phosphatase, has been shown to activate the cyclin-dependent kinases at different points of the cell cycle. CDC25A has been shown to affect S phase entry and possibly the initiation of mitosis. CDC25A dephosphorylates cyclin dependent kinases, including Cdk2, Cdk4, as well as non cyclin proteins such as the homeodomain transcription factor cut, the proto-oncogene Raf-1. CDC25A has been implicated in many carcinomas, including those of the colon, lymph node, stomach, ovary, breast. CDC25A is located on chromosome 3p21 in an area frequently involved in karyotypic abnormalities in renal carcinomas, small cell carcinomas of the lung, and benign tumors of the salivary gland.

Gene Name: cell division cycle 25A
Family/Subfamily: Protein Phosphatase , CDC25
Synonyms: CDC25A, CDC25A2-CAG isoform, Cell division cycle 25A, CDC25A phosphatase, CDC25Hu1, M-phase inducer phosphatase 1, CDC25A2
Target Sequences: NM_001789 NP_001780.2 P30304

Publications (1)

1
Pro-apoptotic role of Cdc25A: activation of cyclin B1/Cdc2 by the Cdc25A C-terminal domain. Chou ST, Yen YC, Lee CM, Chen MS. The Journal of biological chemistry. 2010 285:17833-45. [PubMed:20368335] [PMC:PMC2878547] Related Antibodies: LS-C97430.

☰ Filters
Antibodies (140)
ELISA Kits (7)
Proteins (7)
Cell-Based (1)
Cell-Based Phosphorylation (4)
Over-Expression Lysate (2)
Primary (140)
Recombinant (5)
Sandwich (2)
CDC25A (154)
Human (141)
Mouse (57)
Rat (57)
Bovine (8)
Chimpanzee (6)
Dog (5)
Gibbon (3)
Horse (5)
Monkey (4)
Rabbit (5)
IHC (65)
IHC-Fr (6)
IHC-P (19)
WB (124)
DB (7)
ELISA (71)
ICC (1)
IF (15)
IP (18)
Peptide-ELISA (12)
rabbit (135)
mouse (5)
Product Group
IHCPlus (1)
Ig (1)
IgG (93)
IgG2a (4)
IgG2a,k (2)
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monoclonal mc (5)
polyclonal pc (135)
3D5 (1)
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Unconjugated (81)
pSer75 (18)
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Ser78 (7)
aa271-300 (7)
pSer278 (7)
pSer293 (7)
pSer79 (7)
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C-Terminus (4)
aa51-100 (4)
20-100 aa (2)
120-200 aa (1)
30-110 aa (1)
450-530 aa (1)
60-140 aa (1)
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Internal (1)
Leu171 (1)
aa122-171 (1)
aa144-193 (1)
aa175-225 (1)
aa473-522 (1)
aa90-139 (1)
p124 (1)
p75 (1)
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No (153)
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Adherent Cell Cultures (5)
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6His, N-terminus (1)
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Human (6)
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Purified (3)
CDC25A Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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CDC25A Rabbit anti-Human Polyclonal (pThr507) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CDC25A Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
61 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365; 200 µg/$484
CDC25A ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
CDC25A Antibody - Anti-CDC25A antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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CDC25A Rabbit anti-Human Polyclonal (aa271-300) Antibody
Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
CDC25A Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using CDC25A (Phospho-Ser178) Antibody. The picture on the right is blocked with the phospho peptide.
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CDC25A Rabbit anti-Human Polyclonal (pSer178) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CDC25A ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$834
CDC25A Antibody - Immunohistochemical analysis of CDC25A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX. w
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CDC25A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
CDC25A Antibody - 1:200 staining mouse brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CDC25A Rabbit anti-Human Polyclonal (pSer178) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CDC25A Antibody - 1:200 staining mouse brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CDC25A Rabbit anti-Human Polyclonal (pThr507) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CDC25A Antibody - 1:200 staining human esophagus tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CDC25A Rabbit anti-Human Polyclonal (pSer75) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CDC25A Antibody - 1:200 staining human esophagus tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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CDC25A Rabbit anti-Human Polyclonal (pSer124) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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CDC25A Rabbit anti-Human Polyclonal (20-100 aa) Antibody
Mouse, Rat, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CDC25A Antibody - Immunohistochemistry of paraffin-embedded human lung carcinoma using CDC25A (Phospho-Ser75) Antibody.
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CDC25A Rabbit anti-Human Polyclonal (pSer75) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$357
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CDC25A Rabbit anti-Human Polyclonal (pSer124) Antibody
IF, IHC, WB
Unconjugated
200 µl/$734
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CDC25A Rabbit anti-Human Polyclonal (pSer124) (Biotin) Antibody
Human
ELISA, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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CDC25A Rabbit anti-Human Polyclonal (pSer124) (FITC) Antibody
Human
ELISA, IF, IHC, WB
FITC Conjugated
200 µl/$952
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CDC25A Rabbit anti-Human Polyclonal (pSer124) (APC) Antibody
Human
ELISA, IF, IHC, WB
APC Conjugated
200 µl/$952
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CDC25A Rabbit anti-Human Polyclonal (pSer124) (Azide-free) (HRP) Antibody
Human
ELISA, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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CDC25A Rabbit anti-Human Polyclonal (pSer124) (PE) Antibody
Human
ELISA, IF, IHC, WB
PE Conjugated
200 µl/$952
CDC25A Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using CDC25A Polyclonal Antibody at dilution of 1:50.
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CDC25A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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CDC25A Rabbit anti-Human Polyclonal (pThr507) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
CDC25A Rabbit anti-Human Polyclonal (pSer278) (FITC) Antibody
Human
ELISA, IHC, IP, WB
FITC Conjugated
200 µl/$952
Select
CDC25A Rabbit anti-Human Polyclonal (pSer278) (PE) Antibody
Human
ELISA, IHC, IP, WB
PE Conjugated
200 µl/$952
Select
CDC25A Rabbit anti-Human Polyclonal (pSer278) (APC) Antibody
Human
ELISA, IHC, IP, WB
APC Conjugated
200 µl/$952
Select
CDC25A Rabbit anti-Human Polyclonal (pSer278) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, IP, WB
HRP Conjugated, Azide-free
200 µl/$952
Viewing 1-25 of 154 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).