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CDC23

cell division cycle 23

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Gene Name: cell division cycle 23
Synonyms: CDC23, ANAPC8, APC8, Cell division cycle 23, CUT23, Cyclosome subunit 8
Target Sequences: NM_004661 NP_004652.2 Q9UJX2

Publications (3)

1
Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits. Tran K, Mahr JA, Choi J, Teodoro JG, Green MR, Spector DH. Journal of virology. 2008 82:529-37. [PubMed:17942546] [PMC:PMC2224378]
2
Cdc20 is required for the post-anaphase, KEN-dependent degradation of centromere protein F. Gurden MD, Holland AJ, van Zon W, Tighe A, Vergnolle MA, Andres DA, Spielmann HP, Malumbres M, Wolthuis RM, Cleveland DW, Taylor SS. Journal of cell science. 2010 123:321-30. [PubMed:20053638] [PMC:PMC2816182]
3
Proteasome-dependent disruption of the E3 ubiquitin ligase anaphase-promoting complex by HCMV protein pUL21a. Fehr AR, Gualberto NC, Savaryn JP, Terhune SS, Yu D. PLoS pathogens. 2012 8:e1002789. [PubMed:22792066] [PMC:PMC3390409]

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CDC23 Antibody - Anti-CDC23 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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CDC23 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
CDC23 Antibody - Staining 293 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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CDC23 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
CDC23 Antibody - Formalin-fixed and paraffin-embedded human brain tissue reacted with CDC23 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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CDC23 Rabbit anti-Human Polyclonal (aa140-168) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
CDC23 Antibody - Immunofluorescent analysis of HepG2 cells at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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CDC23 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF
Unconjugated
50 µg/$294; 100 µg/$360
CDC23 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using CDC23 Polyclonal Antibody at dilution of 1:50.
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CDC23 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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CDC23 Mouse anti-Human Monoclonal (aa491-592) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$705
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CDC23 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$904
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CDC23 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$904
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CDC23 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$904
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CDC23 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$904
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CDC23 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$904
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CDC23 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$331
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CDC23 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CDC23 Antibody - Western blot analysis of extracts from 293 cells and COS-7 cells, using APC8 antibody.
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CDC23 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
100 µg/$357
CDC23 Antibody - Western blot of Cdc23 antibody
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CDC23 Rabbit anti-Human Polyclonal (220-300 aa, Internal) Antibody
Mouse, Human, Monkey
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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CDC23 Rabbit anti-Human Polyclonal (aa125-175) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
CDC23 Antibody - Western blot analysis of the lysates from RAW264.7cells using APC8 antibody.
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CDC23 Rabbit anti-Human Polyclonal (aa220-269) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
CDC23 Antibody - Western blot of CDC23 antibody.
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CDC23 Rabbit anti-Human Polyclonal (aa366-597) Antibody
Human
WB
Unconjugated
100 µl/$303; 200 µl/$343; 500 µl/$476; 1 ml/$543; 2 ml/$715; 5 ml/$1,182
CDC23 Antibody - Western blot of CDC23 antibody.
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CDC23 Rabbit anti-Human Polyclonal (aa366-597) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$331; 200 µl/$383; 500 µl/$556; 1 ml/$665; 2 ml/$901; 5 ml/$1,511
CDC23 Antibody - Western blot of CDC23 antibody.
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CDC23 Rabbit anti-Human Polyclonal (aa366-597) (APC) Antibody
Human
WB
APC Conjugated
100 µl/$396; 200 µl/$476; 500 µl/$815; 1 ml/$969; 2 ml/$1,240; 5 ml/$2,325
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CDC23 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CDC23 Antibody - Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CDC23 Rabbit anti-Human Polyclonal (aa101-150) Antibody
Human
WB
Unconjugated
100 µl/$397
CDC23 Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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CDC23 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
CDC23 Antibody - Western blot analysis of CDC23 expression in Jurkat (A) whole cell lysates.
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CDC23 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Bovine, Rat, Human
WB
Unconjugated
100 µl/$299
CDC23 Antibody - Western blot analysis of extracts of various cell lines, using CDC23 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 10s.
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CDC23 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).