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CD95 / FAS
Fas cell surface death receptor
CD95 / FAS is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
| Gene Name: | Fas cell surface death receptor |
| Family/Subfamily: | TNF Receptor , not assigned-TNF Receptor |
| Synonyms: | FAS, ALPS1A, APO-1, APT1, Apo-1 antigen, APO-1 cell surface antigen, Apo11 antigen, Apoptosis antigen 1, CD95 antigen, Delta Fas/APO-1/CD95, Fas AMA, FAS1, Fasl receptors, FASLG receptor, FASTM, FAS 827dupA, Fasl receptor, TNFRSF6, CD95 |
| Target Sequences: | NM_152877 NP_000034.1 P25445 |
Publications (2)
1
Combined evaluation of the FAS cell surface death receptor and CD8+ tumor infiltrating lymphocytes as a prognostic biomarker in breast cancer. Blok EJ, van den Bulk J, Dekker-Ensink NG, Derr R, Kanters C, Bastiaannet E, Kroep JR, van de Velde CJ, Kuppen PJ. Oncotarget. 2017 8:15610-15620. (Flo; Human)
[Full Text Article]
[PubMed:28121628]
[PMC:PMC5362509]
Related Antibodies: LS-B2820.
2
Apoptosis of Hepatocellular Carcinoma Cells Induced by Nanoencapsulated Polysaccharides Extracted from Antrodia Camphorata. Chang JS, Kuo HP, Chang KL, Kong ZL. PloS one. 2015 10:e0136782. (IHC; Human)
[Full Text Article]
[PubMed:26327534]
Related Antibodies: LS-C179869.
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CD95 / FAS Mouse anti-Human Monoclonal (LT95) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
0.05 mg/$460
CD95 / FAS Mouse anti-Human Monoclonal (PE) (LT95) Antibody
Human
Flo, IHC-P
PE Conjugated
100 Tests/$365
CD95 / FAS Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
CD95 / FAS Goat anti-Human Polyclonal (aa224-237) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$485
CD95 / FAS Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
CD95 / FAS Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Mouse, Rat
IF, IHC-P, WB
Unconjugated
50 µg/$460
CD95 / FAS Mouse anti-Human Monoclonal (PE) (UB2) Antibody
Human
Flo, IHC
PE Conjugated
50 Tests/$452
CD95 / FAS Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$403; 200 µg/$575
CD95 / FAS Mouse anti-Human Monoclonal (CH11) Antibody
Human
Flo, ICC, WB
Unconjugated
50 µg/$1,001
CD95 / FAS Rabbit anti-Rat Polyclonal (N-Terminus) (Magnetic beads) Antibody
Mouse, Rat
IP
Magnetic beads Conjugated
100 µg/$399
CD95 / FAS Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
Cancer
CD95 / FAS Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
CD95 / FAS Rat anti-Mouse Monoclonal (Biotin) Antibody
Mouse, Bovine
IP, WB
Biotin Conjugated
100 µl/$1,089
CD95 / FAS Rabbit anti-Cow Polyclonal (aa37-274) Antibody
Bovine, Cow
WB
Unconjugated
100 µl/$317; 200 µl/$362; 500 µl/$513; 1 ml/$589; 2 ml/$812; 5 ml/$1,324
CD95 / FAS Mouse anti-Human Monoclonal Antibody
Human
Flo, ICC, IHC, IHC-Fr
Unconjugated
100 µg/$625
CD95 / FAS Rabbit anti-Human Polyclonal (aa281-330) Antibody
Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
CD95 / FAS Rabbit anti-Rat Monoclonal (PE) (028) Antibody
Rat
Flo
PE Conjugated
25 Tests/$293; 100 Tests/$376
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
17.6 kDa
5 µg/$268; 20 µg/$349
CD95 / FAS Mouse anti-Human Monoclonal (APO-1-3) Antibody
Human
Flo, Func, IP, WB
Unconjugated
50 µg/$295
CD95 / FAS Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo, IHC, IHC-Fr, IP
FITC Conjugated
100 Tests/$548
CD95 / FAS Mouse anti-Human Monoclonal (PE, Cy5) Antibody
Human
Flo, IHC, IHC-Fr, IP
PE, Cy5 Conjugated
100 Tests/$564
CD95 / FAS Rabbit anti-Human Polyclonal (230-310 aa) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CD95 / FAS Rabbit anti-Rat Polyclonal (aa87-109) Antibody
Rat
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$723
CD95 / FAS Mouse anti-Human Monoclonal (UB2) Antibody
Human
Flo, IHC
Unconjugated
100 µg/$481
CD95 / FAS Mouse anti-Human Monoclonal (4F8H6) Antibody
Human
Flo, ICC, IF, WB
Unconjugated
100 µg/$503
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