Rat CD95 / FAS

Rabbit

Rat, Mouse (tested or 100% immunogen sequence identity)

IgG Polyclonal

Unconjugated

Immunoaffinity purified

Unmodified

Synthetic peptide from the N-Terminus of rat CD95 (YTDRKHYSDKCRRCAFCDEGHGL, aa87-109 of UniProt Q63199). Percent identity by BLAST analysis: Rat (100%); Hamster (83%); Human, Mouse (74%).

aa87-109

Rat CD95 / FAS

• IHC
• IHC - Paraffin (0.5 - 1 µg/ml)
• IHC - Frozen (0.5 - 1 µg/ml)
• Western blot (0.5 - 1 µg/ml)

FAS (also known as surface antigen APO1 or CD95) is a member of the tumour-necrosis receptor factor family of death receptors, can induce apoptosis or, conversely, can deliver growth stimulatory signals. It acts as an inducer of both neurite growth in vitro and accelerated recovery after nerve injury in vivo. Fas antigen is expressed and functional on papillary thyroid cancer cells and this may have potential therapeutic significance. The FAS antigen shows structural homology with a number of cell surface receptors, including tumor necrosis factor (TNF) receptors and the low-affinity nerve growth factor receptor (NGFR) and is mapped to 10q24.1. And the FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signalling pathway has been shown to participate in immune escape and tumorigenesis.

Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.

Reconstitute in sterile distilled water.

Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.

For research use only. Intended for use by laboratory professionals.

This antibody carries the LSBio 100% Guarantee.

Uniprot: P25445 NCBI: NM_152877 NP_000034.1