Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 341] (IgG1) to Rat CD8B / CD8 Beta
Western blot, Immunoprecipitation, Flow Cytometry, Cytotoxic Assay
Rat CD8B / CD8 Beta
Rat (tested or 100% immunogen sequence identity)
IgG1 Monoclonal 
Protein G purified
Flow Cytometry (0.5 µg/10E6 cells)
Specificity and Use
CD8B / CD8 Beta antibody was raised against rat/mouse T cell hybrids expressing CD8.
Anti-rat CD8b monoclonal antibody reacts with the beta chain of the CD8 differentiation antigen. CD8b is expressed on most thymocytes and mature T cytotoxic/suppressor cells (MHC class I restricted). While the CD8a and CD8b form a heterodimer on the surfa.
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain.