Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone B441] (IgG,k) to Human CD8A / CD8 Alpha
IHC - Frozen, Flow Cytometry
Human CD8A / CD8 Alpha
Human (tested or 100% immunogen sequence identity)
IgG,k Monoclonal [B441]
IHC - Frozen
Specificity and Use
CD8A / CD8 Alpha antibody was raised against stimulated human lymphocytes.
This antibody consists of a disufide-linked / hetrodimer with a mW of 30 kD or an / homodimer with a MW of 32 kD. The CD molecule binds to HLA class I molecule during interaction of CD 8+ T cells with antigen-presenting cells or with target cells. CD 8+T cells include most of the cytotoxic T cells.
50 mM borate, 150 mM sodium chloride, 20 % glycerol, 0.05 % azide, pH 8.0
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain.