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CD8
CD8 (cluster of differentiation 8) is a transmembrane glycoprotein that serves as a co-receptor for the T cell receptor (TCR). Like the TCR, CD8 binds to a major histocompatibility complex (MHC) molecule, but is specific for the class I MHC protein. There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on chromosome 2 in position 2p12. The CD8 co-receptor is predominantly expressed on the surface of cytotoxic T cells, but can also be found on natural killer cells, cortical thymocytes, and dendritic cells. It is expressed in T cell lymphoblastic lymphoma and hypo-pigmented mycosis fungoides. To function, CD8 forms a dimer, consisting of a pair of CD8 chains. The most common form of CD8 is composed of a CD8-alpha and CD8-beta chain, both members of the immunoglobulin superfamily with an immunoglobulin variable (IgV)-like extracellular domain connected to the membrane by a thin stalk, and an intracellular tail. Less-common homodimers of the CD8-alpha chain are also expressed on some cells.
CD8 Target Details
| Target Name: | CD8 |
Publications (4)
1
Inhibition of adaptive immunity by IL9 can be disrupted to achieve rapid T-cell sensitization and rejection of progressive tumor challenges. Hoelzinger DB, Dominguez AL, Cohen PA, Gendler SJ. Cancer research. 2014 74:6845-55. (WB; Mouse)
[Full Text Article]
[PubMed:25297635]
[PMC:PMC4254354]
2
A canine chimeric monoclonal antibody targeting PD-L1 and its clinical efficacy in canine oral malignant melanoma or undifferentiated sarcoma. Maekawa N, Konnai S, Takagi S, Kagawa Y, Okagawa T, Nishimori A, Ikebuchi R, Izumi Y, Deguchi T, Nakajima C, Kato Y, Yamamoto K, Uemura H, Suzuki Y, Murata S, Ohashi K. Scientific reports. 2017 7:8951. (Flo; Dog)
[Full Text Article]
[PubMed:28827658]
[PMC:PMC5567082]
Related Antibodies: LS-C188088.
3
Systemic Blockade of Clever-1 Elicits Lymphocyte Activation Alongside Checkpoint Molecule Downregulation in Patients with Solid Tumors: Results from a Phase I/II Clinical Trial10<sup> Drug Development Unit, Royal Marsden NHS Foundation Trust/Institute of Cancer Research, Sutton, United Kingdom12<sup> Terveystalo Finland, Helsinki, Finland14<sup> MediCity Research Laboratory, University of Turku, Turku, Finland. maijal@utu.fi. Reetta Virtakoivu #, Jenna H Rannikko # , Miro Viitala # , Felix Vaura, Akira Takeda, Tapio Lönnberg, Jussi Koivunen, Panu Jaakkola, Annika Pasanen, Shishir Shetty, Maja J A de Jonge, Debbie Robbrecht, Yuk Ting Ma, Tanja Skyttä, Anna Minchom, Sirpa Jalkanen, Matti K Karvonen, Jami Mandelin, Petri Bono , Maija Hollmén. The Breast : official journal of the European Society of Mastology. 2021 Aug;27:4205-4220. [Full Text Article]
[PubMed:34078651]
Related Antibodies: LS-C311966.
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CD8
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YTS169.4
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(1)
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(14)
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(29)
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(1)
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(64)
Epitope
aa22-187
(1)
Publications
No
(168)
Yes
(3)
Sample Type
Plasma
(8)
Serum
(8)
Tissue Homogenates
(1)
CD8 Rat anti-Mouse Monoclonal (YTS169.4) Antibody
Mouse
Flo, IHC, IHC-Fr
Unconjugated
25 µg/$281; 0.25 mg/$471
CD8 Mouse anti-Human Monoclonal (C8/144B) Antibody
Human
IHC, IHC-Fr, IHC-P
Unconjugated
0.1 ml/$327
CD8 Rat anti-Human Monoclonal (YTC182.20) Antibody
Human
Flo, IF, IHC, IHC-Fr
Unconjugated
0.2 mg/$471
CD8 Mouse anti-Human Monoclonal (UCHT4) Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$284
CD8 Mouse anti-Rat Monoclonal (15-11C5) Antibody
Rat
Flo, IHC, IHC-Fr, IHC-P
Unconjugated
100 µg/$475
CD8 Mouse anti-Human Monoclonal (Preservative Free) (LT8) Antibody
Human
Flo, IHC-Fr, IP
Unconjugated, Preservative Free
1 mg/$645
CD8 Mouse anti-Guinea pig Monoclonal (Supernatant) (CT6) Antibody
Guinea pig
Flo, IHC-Fr
Unconjugated, Supernatant
0.25 ml/$516
CD8 Mouse anti-Rabbit Monoclonal (FITC) (12.C7) Antibody
Rabbit
Flo
FITC Conjugated
0.1 mg/$534
CD8 Rat anti-Human Monoclonal Antibody
Human, Monkey, Cynomolgus
Flo, IHC, IHC-Fr
Unconjugated
200 µg/$732
CD8 Mouse anti-Human Monoclonal Antibody
Human, Monkey
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$562; 200 µg/$763
CD8 Rat anti-Dog Monoclonal (YCATE55.9) Antibody
Dog
Flo, IF, IHC-Fr
Unconjugated
0.1 mg/$457
CD8 Rat anti-Dog Monoclonal (RPE) (YCATE55.9) Antibody
Dog
Flo
RPE Conjugated
100 Tests/$732
CD8 Mouse anti-Human Monoclonal (Supernatant) (4B11) Antibody
Human
IHC-Fr, IHC-P
Unconjugated, Supernatant
0.1 ml/$328; 1 ml/$1,080
CD8 Mouse anti-Human Monoclonal (APC, Cy5.5) (RFT8) Antibody
Human
Flo
APC, Cy5.5 Conjugated
100 Tests/$448
CD8 Mouse anti-Human Monoclonal (AF647) (OKT-8) Antibody
Human
Flo
AF647 Conjugated
20 Tests/$242; 100 Tests/$289; 200 Tests/$331
CD8 Mouse anti-Human Monoclonal (B362) Antibody
Human
ELISA, Flo, IF, IHC-Fr
Unconjugated
0.2 mg/$328
CD8 Mouse anti-Human Monoclonal Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
100 µg/$434
CD8 Mouse anti-Sheep Monoclonal Antibody
Goat, Sheep, Bovine
Flo, IHC-Fr, IP
Unconjugated
0.1 mg/$395
CD8 Mouse anti-Sheep Monoclonal (PE) Antibody
Goat, Sheep, Bovine
Flo
PE Conjugated
100 Tests/$896
CD8 Mouse anti-Human Monoclonal (LT8) Antibody
Human
Flo, IHC, IHC-Fr, IP
Unconjugated
0.1 mg/$378
CD8 Mouse anti-Human Monoclonal (B334) Antibody
Human
Flo, IF, IHC
Unconjugated
0.2 mg/$328
Sandwich
96-Well Microplate
Mouse
1.25 - 80 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
CD8 Mouse anti-Human Monoclonal (Biotin) (UCHT4) Antibody
Human
ELISA, Flo, ICC, WB
Biotin Conjugated
100 µg/$446
CD8 Mouse anti-Human Monoclonal (FITC) (UCHT4) Antibody
Human
ELISA, Flo, ICC, WB
FITC Conjugated
120 Tests/$446
CD8 Mouse anti-Cat Monoclonal Antibody
Cat
Flo, IHC, IHC-Fr, IP
Unconjugated
500 µg/$558
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