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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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CD74 / CLIP Antibody (clone AT 14/19) LS‑C44748
Note: This antibody replaces LS-C57914
Antibody
CLIP antibody LS-C44748 is an unconjugated mouse monoclonal antibody to human CLIP (CD74). Validated for Flow and IP.
Catalog
Size
Price
LS-C44748-200
200 µg (1 mg/ml)
Unavailable

Popular CD74 / CLIP Products

Antibody
Species: Human
Applications: Flow Cytometry
Anti-CD74 antibody IHC of human tonsil, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7443 concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Immunoprecipitation, Flow Cytometry
Western blot of H-2 class II histocompatibility antigen gamma chain antibody at 2 ug/ml with mouse spleen tissue Secondary Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 34 KDa. Observed band size: 34 KDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Mouse
Applications: Western blot, ELISA
Western blot analysis of CD74 expression in Ramos (A); Raji (B); PC12 (C) whole cell lysates.
Species: Human, Rat
Applications: Western blot
IHC analysis of formalin/paraffin human tonsil with CLIP antibody (CLIP/813).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Species: Human
Applications: IHC, IHC - Paraffin, Immunofluorescence, Flow Cytometry

Product Description

CLIP antibody LS-C44748 is an unconjugated mouse monoclonal antibody to human CLIP (CD74). Validated for Flow and IP.
About CD74 / CLIP
Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. P04233 NM_004355 NP_004346.1

CD74 Antibody, CD74 antigen Antibody, DHLAG Antibody, HLADG Antibody, HLA-DR-gamma Antibody, Ia-associated invariant chain Antibody, p33 Antibody, MHC HLA-DR gamma chain Antibody, Ia-GAMMA Antibody


Specifications

Target
Human CD74 / CLIP
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [AT 14/19]
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Immunoprecipitation
  • Flow Cytometry (1:50 - 1:200)
Immunogen
CD74 / CLIP antibody was raised against namalwa human B-cell line.
Specificity
Recognizes human CD74, a type II transmembrane protein, which is also known as the MHC class II associated invariant chain. The CD74 molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed by B cells, monocytes, dendritic cells and other antigen presenting cells, and by various types of carcinoma. Expression of CD74 is primarily intracellular with moderate expression at the cell surface of B cells and monocytes. *Membrane permeabilization may enhance CD74 staining on monocytes but is not required when staining lymphocytes. XXX recommend the use of Leucoperm (product code BUF09) for this purpose.
Usage
Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Method sheets are available on request.
Presentation
PBS, pH 7.4, 0.09% sodium azide.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.

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Requested From: 
Date Requested: 6/24/2018

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