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Anti-CD74 / CLIP Antibody (C-Terminus, clone BU45, FITC) LS-C44929

Note: This antibody replaces LS-C58028


Wt. Vol. Conc. Price
100 µg - 0.1 mg/ml $335
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)

Most Popular CD74 / CLIP Antibodies

Anti-CD74 / CLIP Antibody (C-Terminus, clone BU45, FITC) LS-C44929
Mouse Monoclonal [clone BU45] (IgG1) to Human CD74 / CLIP
Flow Cytometry
FITC Conjugated

100% Guaranteed 100% Guaranteed
Mouse Monoclonal [clone BU45] (IgG1) to Human CD74 / CLIP
Flow Cytometry
FITC Conjugated


Human CD74 / CLIP
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal [BU45]
Protein G purified


Flow Cytometry (1:1 - 1:5)

Specificity and Use

CD74 / CLIP antibody was raised against b lymphoblastoid cell line HFB1.
Recognizes human CD74, a type II transmembrane protein, which is also known as the MHC class II associated invariant chain. The Recognizes 33, 35 and 41 kD isoforms of CD74. The CD74 molecule plays a critical role in the presentation of peptides, by the MHC class II antigens, to CD4 positive lymphocytes. CD74 is expressed on MHC class II positive cells including B cells, a subset of activated T cells, monocytes, dendritic cells and by various types of carcinoma. Expression of CD74 is primarily intracellular with moderate expression at the cell surface of B cells and monocytes. The Bu45 antibody binds to an epitope within the extracytoplasmic domain of the CD74 molecule, which is distal from the C-terminus. *Membrane permeabilization may enhance CD74 staining on monocytes but is not required when staining lymphocytes. XXX recommend the use of Leucoperm (product code BUF09) for this purpose.
Flow Cytometry: Use 10 ul of the suggested working dilution to label 1x10^6 cells in 100 ul. Method sheets are available on request.


PBS, pH 7.4, 0.09% sodium azide, 1% BSA.
+4°C or -20°C, Avoid repeated freezing and thawing.
For research use only.

About CD74 / CLIP

P04233 NM_004355 NP_004346.1

CD74 Antibody, CD74 antigen Antibody, DHLAG Antibody, HLADG Antibody, HLA-DR-gamma Antibody, Ia-associated invariant chain Antibody, p33 Antibody, MHC HLA-DR gamma chain Antibody, Ia-GAMMA Antibody

Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.

Requested From: United States
Date Requested: 10/27/2016

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