Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 1E6] (IgG2b,k) to Human CD71 / Transferrin Receptor
IHC - Paraffin, Western blot, ELISA
Mouse Monoclonal [clone SOM4D10] (IgG2b)
IHC - Frozen
CD71 / Transferrin Receptor
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [SOM4D10]
IHC - Frozen (1:130 - 1:400)
Specificity and Use
The antigen is CD71. The epitope has not been further characterized. Antigen distribution: Isolated cells: The antibody stains > 90% of activated human peripheral blood lymphocytes in flow cytometry. Tissue sections: Germinal center; basal layer of epidermis; tissue macrophages; testis. Specificity: Human: CD71 Other: not tested.
Lyophilized from PBS pH 7.2, 5mg/ml BSA, and 0.09% sodium azide
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity.