Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone B331] (IgG1,k) to Human CD71 / Transferrin Receptor
IHC, Immunofluorescence, Flow Cytometry
Human CD71 / Transferrin Receptor
Human (tested or 100% immunogen sequence identity)
IgG1,k Monoclonal [B331]
IHC (10 - 20 µg/ml)
Immunofluorescence (10 - 20 µg/ml)
Specificity and Use
CD71 / Transferrin Receptor antibody was raised against cell line KG1.
This antibody reacts with the transferrin receptor, a 180-190 kD transmembrane glycoprotein which exists as a 95 kD homodimer with interchain disulfide bond. The specificity of this antibody, as demonstrated by immunoprecipitation, are equivalent to OKT9, B3/25, and BerT9.
50 mM sodium borate, 150 mM sodium chloride, 20% glycerol, 0.05% sodium azide, pH 8.0
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system By similarity.