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CD66a / CEACAM1
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CD66a / CEACAM1 encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
| Gene Name: | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) |
| Family/Subfamily: | CEA , not assigned-CEA |
| Synonyms: | CEACAM1, Antigen CD66, BGP1, Biliary glycoprotein 1, CD66a, BGP-1, BGP, BGPI, CD66a antigen |
| Target Sequences: | NM_001712 NP_001703.2 P13688 |
Publications (5)
1
Invasive Ductular Reaction Operates Hepatobiliary Junctions upon Hepatocellular Injury in Rodents and Humans. Clerbaux LA, Manco R, Van Hul N, Bouzin C, Sciarra A, Sempoux C, Theise ND, Leclercq IA. The American journal of pathology. 2019 August;189:1569-1581. [Full Text Article]
[PubMed:31108103]
Related Antibodies: LS-C106710.
2
Compensatory hepatic adaptation accompanies permanent absence of intrahepatic biliary network due to YAP1 loss in liver progenitors10<sup> Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA12<sup> Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, USA; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA14<sup> Division of Gastroenterology, Hepatology, and N. Laura M Molina, Junjie Zhu, Qin Li, Tirthadipa Pradhan-Sundd, Yekaterina Krutsenko, Khaled Sayed, Nathaniel Jenkins, Ravi Vats, Bharat Bhushan, Sungjin Ko, Shikai Hu, Minakshi Poddar, Sucha Singh, Junyan Tao, Prithu Sundd, Aatur Singhi, Simon Watkins, Xiaochao Ma, Panayiotis V Benos, Andrew Feranchak, George Michalopoulos, Kari Nejak-Bowen, Alan Watson, Aaron Bell, Satdarshan P Monga. Cell reports. 2021 Jul;36:109310. [Full Text Article]
[PubMed:34233187]
[PMC:PMC8280534]
Related Antibodies: LS-C106710.
3
Apical expression of human full-length hCEACAM1-4L protein renders the Madin Darby Canine Kidney cells responsive to lipopolysaccharide leading to TLR4-dependent Erk1/2 and p38 MAPK signalling. Li[Character e9]vin-Le Moal V, Beau I, Rougeaux C, Kansau I, Fabrega S, Brice C, Korotkova N, Moseley SL, Servin AL. Cellular microbiology. 2011 May;13:764-85. [Full Text Article]
[PubMed:21352462]
Related Antibodies: LS-C6024.
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Fast Shipping
CD66a / CEACAM1 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
CD66a / CEACAM1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IHC-Fr
Unconjugated
50 µg/$536; 100 µg/$836
CD66a / CEACAM1 Mouse anti-Mouse Monoclonal (CC1) Antibody
Mouse
Flo, IHC, IHC-P
Unconjugated
25 µg/$288; 100 µg/$432
CD66a / CEACAM1 Mouse anti-Human Monoclonal (2F6) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich
96-Well Strip Plate
Mouse
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$854
CD66a / CEACAM1 Rabbit anti-Human Polyclonal (aa50-77) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
CD66a / CEACAM1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
CD66a / CEACAM1 Mouse anti-Human Monoclonal (aa305-414) Antibody
Human
ELISA
Unconjugated
100 µg/$705
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$685
CD66a / CEACAM1 Mouse anti-Human Monoclonal (APC) Antibody
Human
Flo
APC Conjugated
25 Tests/$278; 100 Tests/$376
CD66a / CEACAM1 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo
FITC Conjugated
25 Tests/$263; 100 Tests/$323
CD66a / CEACAM1 Rabbit anti-Mouse Monoclonal (PE) (117) Antibody
Mouse
Flo
PE Conjugated
25 Tests/$263; 100 Tests/$376
CD66a / CEACAM1 Rabbit anti-Mouse Monoclonal (APC) (117) Antibody
Mouse
Flo
APC Conjugated
25 Tests/$278; 100 Tests/$421
CD66a / CEACAM1 Rabbit anti-Human Monoclonal (Preservative Free) (003) Antibody
Human
ELISA
Unconjugated, Preservative Free
20 µl/$271; 100 µl/$412
CD66a / CEACAM1 Rabbit anti-Human Polyclonal (aa35-320) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
CD66a / CEACAM1 Rabbit anti-Human Polyclonal (aa35-320) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755; 2 ml/$993; 5 ml/$1,716
CD66a / CEACAM1 Mouse anti-Human Monoclonal (7B9G3) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$459
CD66a / CEACAM1 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, IHC-P
Unconjugated
20 µl/$271; 100 µl/$412
CD66a / CEACAM1 Rabbit anti-Mouse Polyclonal Antibody
Mouse
Flo, ICC, IF
Unconjugated
20 µl/$271; 100 µl/$412
CD66a / CEACAM1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$412
CD66a / CEACAM1 Rabbit anti-Human Polyclonal Antibody
Human
Flo, ICC, IF
Unconjugated
20 µl/$271; 100 µl/$412
E. coli
His
33.0 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
E. coli
His
13.8 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
Wheat Germ Extract
GST
77 kDa
10 µg/$479; 25 µg/$670
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