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CD63
CD63 molecule
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
| Gene Name: | CD63 molecule |
| Family/Subfamily: | Tetraspan , not assigned-Tetraspan |
| Synonyms: | CD63, CD63 molecule, LAMP-3, ME491, Granulophysin, MLA1, Tetraspanin-30, Tspan-30, CD63 antigen, OMA81H, TSPAN30 |
| Target Sequences: | NM_001780 NP_001771.1 P08962 |
Publications (8)
1
Down-regulation of CD9 expression and its correlation to tumor progression in B lymphomas. Yoon SO, Zhang X, Freedman AS, Zahrieh D, Lossos IS, Li L, Choi YS. The American journal of pathology. 2010 177:377-86.
[PubMed:20566742]
[PMC:PMC2893680]
2
Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake. Ko SY, Lee W, Kenny HA, Dang LH, Ellis LM, Jonasch E, Lengyel E, Naora H. Communications biology. 2019 October;2: [Full Text Article]
[PubMed:31646189]
[PMC:PMC6802217]
3
Extracellular vesicles from neurons promote neural induction of stem cells through cyclin D1. Lu Song, Xinran Tian, Randy Schekman. The Journal of cell biology. 2021 September;220: [Full Text Article]
[PubMed:34309628]
[PMC:PMC8313409]
Related Antibodies: LS-C179520.
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Cancer Pathology
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CD63 Mouse anti-Human Monoclonal (MEM-259) Antibody
Human
Flo, ICC, IHC, IHC-P, IP
Unconjugated
0.1 mg/$460
CD63 Mouse anti-Human Monoclonal (Biotin) (MEM-259) Antibody
Human
Flo, ICC, IHC-P, IP
Biotin Conjugated
0.1 mg/$337
CD63 Rabbit anti-Human Polyclonal (aa163-190) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$460
CD63 Rat anti-Mouse Monoclonal (R5G2) Antibody
Mouse
Flo, WB
Unconjugated
100 µl/$413
CD63 Goat anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Human, Monkey
IF, WB
Unconjugated
600 µg/$422
CD63 Rabbit anti-Human Monoclonal (Preservative Free) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
CD63 Mouse anti-Rat Monoclonal (AD1) Antibody
Rat
Flo, IHC, IHC-P, IP, WB
Unconjugated
25 µg/$285; 0.1 mg/$395
CD63 Rabbit anti-Human Polyclonal (aa163-190) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
CD63 Rabbit anti-Human Polyclonal (aa163-190) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
CD63 Rabbit anti-Human Polyclonal (aa163-190) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
CD63 Mouse anti-Human Monoclonal (Biotin) (AHN16.1/46-4-5) Antibody
Human
Flo
Biotin Conjugated
100 µg/$626
CD63 Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
Cancer Pathology
Cancer
CD63 Mouse anti-Human Monoclonal (MX-49.129.5) Antibody
Mouse, Human
Flo, IF, IHC-P, WB
Unconjugated
50 µg/$460
CD63 Rabbit anti-Human Polyclonal (121-170 aa, Internal) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
CD63 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Sandwich
96-Well Strip Plate
Human
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$783
Sandwich
96-Well Strip Plate
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
E. coli
6His, N-terminus
14 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Tissue Homogenates
1 Plate/$798
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Tissue Homogenates
1 Plate/$818
Cancer Pathology
Cancer
CD63 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P, WB
Unconjugated
50 µl/$460
CD63 Rabbit anti-Human Polyclonal (aa152-201) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
Cancer Pathology
Cancer
CD63 Mouse anti-Human Monoclonal (AHN16.1/46-4-5) Antibody
Human
Flo, ICC, IHC, IHC-P
Unconjugated
50 µg/$440
CD63 Mouse anti-Human Monoclonal (Biotin) (AHN16.1/46-4-5) Antibody
Human
Flo, ICC
Biotin Conjugated
100 µg/$511
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