Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone 12435] (IgG1) to Human CD63
Human (tested or 100% immunogen sequence identity)
IgG1 Monoclonal 
Specificity and Use
CD63 antibody was raised against human cytochrome-B enriched cells.
This antibody is directed against the CD63 antigen which is expressed in platelet lysosomes and is translocated to the platelet surface upon activation with strong agonists. The antigen is also present in most peripheral blood cells( not erythrocytes) and in many tissues; both surface and cytoplasmic locations are reported.
20 mM Tris, pH 8.0, 150 mM sodium chloride, 10 mg BSA
Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2.