Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC - Frozen, Western blot, Flow Cytometry, Functional Assay
Mouse Monoclonal (IgG1,k) to Human CD59
IHC, Flow Cytometry
Human (tested or 100% immunogen sequence identity)
Protein A purified
Flow Cytometry (1:50)
Specificity and Use
CD59 antibody was raised against human K562 tumor cells.
Reacts with the 18-22kD CD59 molecule.
Suitable for use in Flow Cytometry and Immunohistochemistry. Flow Cytometry: 1:50 (~80 ul/test). The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation.