Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Human (tested or 100% immunogen sequence identity)
Protein A purified
IHC - Paraffin (1:50)
Specificity and Use
CD59 antibody was raised against human K562 tumor cells.
Reacts with the 18-22kD CD59 molecule.
Suitable for use in Flow Cytometry. Use 80ul of a 1:50 dilution for 5x10e5 cells (aliquot contains enough antibody to perform 60 FC tests using these conditions). The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.
Supplied as a liquid in PBS, pH 7.5, 5% Glycerol, 0.2% BSA, 0.04% sodium azide.
+4°C (short-term), -20°C (long-term). Protect from light.
CD59 is a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation.
Anti-CD59 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6568 dilution 1:50. This image was taken for the unconjugated form of this product. Other forms have not been tested.